Cell Respiration and Cell Survival (eBook)

In this book, the current understanding of the mechanisms of each beta cell toxins are reviewed, reported toxin resistant insulinoma or immortalized beta cells are summarized, and the different nature of those toxin resistant cells are analyzed. With advancements in cancer stem cell research, the possible involvement of stem cells enrichment after various toxin challenges is also discussed. Moreover, there is a renewed interest in the study of the function of fatty acid synthase (FASN) and fatty-acid synthesis in cancer pathogenesis. This book outlines the role of FASN in cancer development and the preclinical development of FASN inhibitors and their antitumor effects. In addition, Parkinson disease (PD) is a neurodegenerative disorder characterized by a progressive loss of the nigrostriatal dopaminergic neurons. The authors discuss the roles of oxidative modification of the proteins of mitochondrial respiration in the pathogenesis of PD. Furthermore, it has been currently understood that the key role in the physiological and regenerative restoration of adult tissues belongs to adult stems cells. Adult stem cell survival after the action ionizing radiation, hyperthermia and in the conditions of the "e;ischemia/reperfusion"e; reaction development are examined.