A Handbook for DNA–Encoded Chemistry – Theory and Applications for Exploring Chemical Space and Drug Discovery

This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book:



Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry
Helps chemists generate and screen novel chemical libraries of large size and quality
Bridges interdisciplinary areas of DNA-encoded combinatorial chemistry - synthetic and analytical chemistry, molecular biology, informatics, and biochemistry
Shows medicinal and pharmaceutical chemists how to efficiently broaden available "chemical space" for drug discovery
Provides expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods