Synaptosomes

Introduction to Synaptosome Methods and Applications.- Victor P. Whittaker: The Discovery of the Synaptosome and Its Implications.- Synaptosome Preparations: Which Procedure Should I Use?.- Protocol for a High-Throughput Semi-Automated Preparation for Filtered Synaptoneurosomes.- Subcellular Fractionation of Brain Tissue from Small Tissue Explants.- Preparation of P2 of Percoll-Purified Synaptosomes from Mammalian Brain Tissue.- Synaptosomal Bioenergetics and Glutamate Release.- Synaptosomes Bioenergetics and Calcium Handling: Aging Response.- Isolation of Highly Purified and Functionally Active Synaptic Mitochondria.- Affinity Proteomics for Interactome and Phosphoproteome Screening in Synaptosomes.- Manipulating Synapse-Enriched Biochemical Fractions to Detect a Purified Synaptic Protein’s Effect on Neurotransmitter Release.- Prosomes: Supramolecular Structures at the Synaptosome Membrane Involved in Vesicle Docking, Fusion,and Neurotransmitter Release.- SMPL-Synaptic Membranes: Nanodisc-Mediated Synaptic Membrane Mimetics Expand the Toolkit for Drug Discovery and the Molecular Cell Biology of Synapses.- Profiling of MicroRNA and Protein from Purified Synaptoneurosomes in a Neurodegenerative Disease Model.- Use of Synaptoneurosome Samples to Study Development and Plasticity of Human Cortex.- The Use of Synaptosomes in Studying Autism Spectrum Disorder and Other Neurodevelopmental Disorders.- Flow Cytometric Evaluation of Crude Synaptosome Preparation as a Way to Study Synaptic Alteration in Neurodegenerative Diseases.