The Micronucleus Assay in Toxicology (eBook)

A Short Personal History of Micronuclei; Mechanisms by which Genotoxins Cause Micronuclei and Other Nuclear Anomalies; The Fate of Micronuclei and Micronucleated Cells; Micronuclei and their Association with Infertility, Pregnancy Complications, Developmental Defects, Anaemias, Inflammation, Diabetes, Chronic Kidney Disease, Obesity, Cardiovascular Disease, Neurodegenerative Diseases and Cancer; The Cytokinesis-Block Micronucleus Cytome Assay in Human Lymphocytes; Micronucleus Cytome Assay with Buccal Cells; Experiments with Micronucleus Assays Using Nasal, Urothelial and Cervical Human Cells; Micronuclei in Bone Marrow Cells of Rodents; The in vitro Micronucleus Assay with Rodent Hepatocytes; Micronucleus Assays with Human Lymphocytes for in vitro Genetic Toxicology Testing; The Micronucleus (Mn) Assay Using Human-derived Cells; Micronucleus Experiments with Non-Human Mammalian Cells; Micronucleus Experiments with Fish Cell Lines; The Piscine Erythrocyte Micronucleus Cytome Assay; Micronucleus Experiments with Reptiles; Micronucleus Assays in Amphibians; Micronucleus Experiments with Bivalve Molluscs; Micronucleus Assays with Meiotic Pollen Tetrad Cells of Tradescantia and with Mitotic Root Tip Cells of Allium cepa and Vicia faba; Automated Identification and Scoring of Micronuclei; Regulatory Aspects and Guidelines for the Use of Micronucleus Assays in Mammalian and Human Cells; Micronucleus Assay: Epidemiological and Statistical Issues; Effects of Tobacco Smoking on Micronucleus Frequency; Khat, Betel, Coca and Tobacco Chewing: Genotoxic Effects in Micronucleus Assays; Electromagnetic Fields and Micronuclei; Use of the Micronucleus Assay in Occupational Studies Involving Exposure to Genotoxic Chemicals - An Overview; Ionising Radiation Exposure Biodosimetry Using the Lymphocyte Cytokinesis-Block Micronucleus Cytome Assay; Heavy Metals I - Lead, Mercury and Cadmium and their Impact on DNA Damage Measured by the Micronucleus Assay; Heavy Metals II - Arsenic, Chromium, Nickel, Vanadium and Micronuclei; Effect of in vivo Formaldehyde Exposure on DNA Damage Measured by the Micronucleus Assay in Lymphocytes, Buccal Cells and Nasal Cells; Pesticide Exposure and Effects on Micronucleus Frequency; Petroleum, its Derivatives and Micronuclei; Butadiene and its Effects on Micronucleus Frequency; The Effect of Dust, Asbestos and Other Fibers on DNA Damage Measured Using the Micronucleus Assays; Use of Micronucleus Assays to Measure DNA Damage Caused by Coal Dust and Ash; Micronucleus Assay as Cytogenetic Biomarker of Ethylene Oxide Exposure; Use of Micronucleus Assays to Measure DNA Damage Caused by Cytostatic/Antineoplastic Drugs; Micronucleus Assay for Assessing Chromosomal Damage of Medical Workers Exposed to Anaesthetic Gases; Micronucleus Induction by Exposure to Vinyl Chloride