Phospholipid-Binding Antibodies

E. Nigel Harris, Thomas Exner, Graham R. V. Hughes, Ronald A. Asherson

SECTION I: PHOSPHOLIPIDS AND CLOTTING. Structures and Properties of Self-Assembled Phospholipids in Excess Water (Ching-Hsien Huang). Phospholipids and the Clotting Process (Robert F.A. Zwaall, Edouard M. Bevers, Jan Rosing). SECTION II: THE IMMUNOLOGY OF PHOSPHOLIPID BINDING AUTOANTIBODIES. Autoantibodies: Their Nature and Significance (Keith B. Elkon). Antibodies to Lipids and Lipid Membranes: Reactions with Phosphatidyl-Choline, Cholesterol, Liposomes, and Bromolin-Treated Erythromytes (Carl R. Alving). Phospholipid Binding Antibodies in Natural and Experimental Syphilis (Konrad Wicher, Victoria Wicher). Role of Monoclonal Antibodies in Understanding the Interactions Between Anti-Phospholipid Antibodies and Phospholipids (Joyce Rauch, Andrew S. Janoff). The Immunology of Phospholipid Binding Antibodies in the Anti-Phospholipid Syndrome and Related Disorders (E. Nigel Harris, Genesio Balestrieri, Angela Tincani, Azzudin E. Gharavi). SECTION III: MEASUREMENT OF PHOSPHOLIPID BINDING ANTIBODIES. Lupus Anticoagulants: Characteristics, Methods of Laboratory Detection and Some Clinical Associations (Thomas Exner, Douglas Triplett). Acquired Circulating Anticoagulants Other Than Lupus Anticoagulants (Thomas Exner, David Green). The Anti-Cardiolipin Assay (E. Nigel Harris, Azzudin E. Gharavi, Graham R.V. Hughes). SECTION IV: PHOSPHOLIPID BINDING ANTIBODIES AND THROMBOSIS. Arterial Thrombosis: Diagnosis and Management (H. Patrick McNeil, Steven A. Krilis, Colin Chesterman). Spontaneous (Unexplained) Thrombosis: The Inherited Basis for the Thrombohemorrhagic Balance (Helge Stormorken). The Pathogenic Role of Anti-Phospholipid Antibodies in Thrombosis (Ronald H. Derksen, Paula Hasselaar, Ph.G. DeGroot). Anti-Phospholipid Antibodies and Impairment of Prostacyclin Synthesis by Endothelium (Luis O. Carreras, Jos Vermylen). Anti-Phospholipid Autoantibodies in Thrombosis: Cause and/or Consequence of the Rupture of the Protein C-Dependent Hemostatic Balance (Jean-Marie Freyssinet, Catherine Ravanat, Lelia Grunebaum, Marie Louise Wiesel, Jean Pierre Cazenave). SECTION V: PHOSPHOLIPID BINDING ANTIBODIES AND PREGNANCY LOSS. Habitual Abortion (Dwight D. Pridham, Christine L. Cook). Pregnancy in SLE (Michael D. Lockshin). Treatment of Anti-Phospholipid Antibody Mediated Fetal Loss: The Case for Corticosteroid Therapy (Neil S. Pattison, Wilhelm F. Lubbe). Clinical Implication of Anti-Phospholipid Antibodies: The Utah Experience (Ware D. Branch, James R. Scott). Alternative Approaches to Treatment of Women with Anti-Phospholipid Antibodies and Fetal Loss (Susan F. Cowchock). Anti-Phospholipid Antibodies and Fetal Loss-Proposed Mechanism (Neil A. MacLachland, Murdo G. Elder). SECTION VI: THE ANTI-PHOSPHOLIPID SYNDROME. The "Anti-Phospholipid Syndrome" - An Introduction (E.Nigel Harris). The "PRIMARY" Anti-Phospholipid Syndrome (Ronald A. Asherson). Anti-Phospholipid Antibodies: Clinical Complications Reported in the Literature (Ronald A. Asherson). Hematological Immune Cytopenias and Anti-Phospholipid Antibodies (Munther A. Khamashta, Samuel J. Machin). Anti-Phospholipid Syndrome in Murine Lupus (Azzudin E. Gharavi). Anti-Phospholipid Antibodies: A Personal History (Graham R.V. Hughes).