Targeted Nanosystems for Therapeutic Applications

Marc A. Ilies is Associate Professor in the Department of Pharmaceutical Sciences of Temple University School of Pharmacy in Philadelphia, PA. His research interests lie in the broadly defined area of bio-organic & medicinal chemistry/chemical biology at membrane interfaces, where he combines heterocyclic chemistry and drug design, materials sciences and pharmaceutical sciences to generate novel therapeutic entities with a high therapeutic index. Ilies is particularly interested in pyridinium derivatives, their synthesis, physicochemical and biological properties, with a focus on their use in drug and gene delivery systems and towards the generation of novel biomarkers and theranostic systems. Towards supra-molecular chemistry, materials sciences, and nanotechnology his group is active towards synthesis, self-assembling, physicochemical and biological properties of assemblies of amphiphilic molecules of different molecular weights and packing parameters (surfactants, gemini surfactants, lipophilic oligomeric surfactants, lipids, dendrons, polymers) and in their interfacial engineering for controlling the above-mentioned properties, drug and gene loading and delivery, enzymatic degradation and toxicity. Other interests include tumor biochemistry and impact of hypoxia in tumor development and invasiveness. Ilies authored more than 65 publications, which have been cited over 2500 times, with an H index of 27. He teaches graduate-level courses in Biochemistry, Medicinal Chemistry, and Advanced Drug and Gene Delivery Systems, and he is a member of the editorial board of four peer-reviewed journals on these topics. Ilies chaired several sessions dedicated to different aspects related with the use of self-assembled systems in drug and nucleic acid delivery systems within the ACS Division of Colloid and Surface Chemistry. Besides ACS, he is an active member of AAPS, AACP, ASGCT and Rho Chi Honor Society. Kazuo Sakurai is a Professor in the Department of Chemistry and Biochemistry, University of Kitakyushu, Fukuoka, Japan. Dr. Sakurai has spent 16 years at the central research center of Kanebo Ltd., and was involved in the fundamental research and business development of conductive polymers for batteries, optical polyester resins, and drug delivering systems. He spent three years (1990-1993) in the United States working with Prof. MacKnight in University of Massachusetts Amherst on characterization of polymer blends via X-ray and neutron scattering. This work constituted the base of PhD thesis, received from Osaka University in 1996. After returning to Japan, Dr. Sakurai was the leader of a research group focused on development of optical-lens polyesters and their product has been used in most of the cell-phones. He worked in the group of Professor Shinkai in JST Project at Kurume from 1999-2001 and has been a Professor since 2001. Professor Sakurai obtained several research funds from CREST/JST (twice), NeXTEP/JST, and National Institute of Biomedical Innovation (NIBIO), which are well-known as the most competitive funding agencies in Japan. He received numerous awards, including Japanese Society of Polymer Science: Technology Award (1994), Best Inventor Award in Japan (1998), Mitsubishi-chemical Polymer Society Award (2008), Daiwa Adrian Prize for Scientific Collaboration from UK Royal Chemical Society (2015), Japanese Society of Polymer Science: Science Award (2018), and Drug Delivery Nagai Award (2018). His major research interests are polysaccharides, polysaccharide/polynucleotide complexes, gene delivery, and small-angle X-ray scattering from soft materials, especially from bio-related materials.

Preface

Chapter 1. Targeted Therapeutic Genome Engineering: Opportunities and Bottlenecks in Medical Translation, Jessica A. Kretzmann, David C. Luther, Marck Norret, Vincent M. Rotello, and K. Swaminathan Iyer
Chapter 2. Aerosol Delivery to the Airways Using Cationic Lipid Nanocomplexes in a Perspective of Cystic Fibrosis Treatment, Mathieu Berchel, Paul-Alain Jaffrès, Tony Le Gall, and Tristan Montier
Chapter 3. Hybrid Nucleic Acid Nanocapsules for Targeted, Enzyme-Specific Drug Delivery and Intracellular Gene Regulation, Joshua J. Santiana, Saketh Gudipati, Alyssa K. Hartmann, and Jessica L. Rouge
Chapter 4. A Novel Polysaccharide Carrier for Functional Oligonucleotides: Immunocyte Targeting through ß-Glucan Receptors, Noriko Miyamoto, Shinichi Mochizuki, and Kazuo Sakurai
Chapter 5. Thiourea-Functional Bioreducible Poly(amido amine)s in Gene Delivery, M. Rachèl Elzes, Guoying Si, Johan F. J. Engbersen, and Jos M. J. Paulusse
Chapter 6. Non-Crosslinking Aggregation of DNA-Functionalized Gold Nanoparticles for Gene Diagnosis and Directed Assembly, Guoqing Wang, Yoshitsugu Akiyama, Naoki Kanayama, Tohru Takarada, and Mizuo Maeda
Chapter 7. Self-Assembly of Noble Metal-Based Hybrid Nanostructures Using a Combination of Colloidal and Aerosol-Based Approaches, Hung-Li Wang and De-Hao Tsai
Chapter 8. Mechanisms of Actively Triggered Drug Delivery from Hard Nanoparticle Carriers, Ajmeeta Sangtani, Megan E. Muroski, and James B. Delehanty
Chapter 9. Inclusion Complexes in Drug Delivery and Drug Targeting: Formation, Characterization, and Biological Applications, Rajesh K. K. Sanku, Ozlem O. Karakus, Monica Ilies, and Marc A. Ilies
Chapter 10. Drug Delivery to Hypoxic Tumors Targeting Carbonic Anhydrase IX, Ahmed M. Shabana and Marc A. Ilies
Chapter 11. Light-Induced Reactive-Oxygen-Species- (ROS-) Mediated Activation of Self-Assembled Nanoplatforms for On-Demand Drug Delivery, Gurusamy Saravanakumar and Won Jong Kim
Chapter 12. Redox Polyion Complex Micelle-Based Injectable Hydrogel as Local Reactive Oxygen Species Scavenging Therapeutics, Long Binh Vong and Yukio Nagasaki
Chapter 13. Colon-Targeted Delivery Systems for Therapeutic Applications: Drug Release from Multiparticulate, Monolithic Matrix, and Capsule-Filled Delivery Systems, Safa Cyrus Fassihi, Rahmat Talukder, and Reza Fassihi

Editors' Biographies

Indexes
Author Index
Subject Index