Huntington’s Disease
Humana Press Inc. (Verlag)
978-1-4939-9296-6 (ISBN)
Authoritative and invaluable, Huntington’s Disease aims to help scientists to significantly extend the breadth and quality of research in laboratories dedicated to mastering and controlling this devastating human condition.
Stereological Methods to Quantify Cell Loss in the Huntington’s Disease Human Brain.- Assessing Autophagic Activity and Aggregate Formation of Mutant Huntingtin in Mammalian Cells.- A Filter Retardation Assay Facilitates the Detection and Quantification of Heat-Stable, Amyloidogenic Mutant Huntingtin Aggregates in Complex Biosamples.- Cellular Models: HD Patient-Derived Pluripotent Stem Cells.- Non-Mammalian Models of Huntington’s Disease.- Mouse Models of Huntington’s Disease.- Motor Assessment in Huntington’s Disease Mice.- Automated Operant Assessments of Huntington’s Disease Mouse Models.- Neurophysiological Assessment of Huntington’s Disease Model Mice.- Murine Models of Huntington’s Disease for Evaluating Therapeutics.- Generating Excitotoxic Lesion Models of Huntington’s Disease.- Large-Brained Animal Models of Huntington’s Disease: Sheep.- Minipigs as Large-Brained Animal Model for Huntington’s Disease: From Behavior and Imaging to Gene Therapy.- Non-Human Primate Models of Huntington’s Disease and Their Application in Translational Research.- In Vivo Multidimensional Brain Imaging in Huntington’s Disease Animal Models.- Magnetic Resonance Imaging in Huntington’s Disease.- Biofluid Biomarkers in Huntington’s Disease.- Assessing and Modulating Kynurenine Pathway Dynamics in Huntington’s Disease: Focus on Kynurenine 3-Monooxygenase.- Assessing Mitochondrial Function in In Vitro and Ex Vivo Models of Huntington’s Disease.- Using Genomic Data to Find Disease-Modifying Loci in Huntington’s Disease (HD).-CRISPR/Cas9-Mediated Genome Editing for Huntington's Disease.- Methods for Assessing DNA Repair and Repeat Expansion in Huntington’s Disease.- Translating Antisense Technology into a Treatment for Huntington’s Disease.- Disease Modification through Trophic Factor Delivery.- Methods to Quantify Cell Signaling and GPCR Receptor Ligand Bias: Characterization of Drugs that Target the Endocannabinoid Receptors in Huntington’s Disease.- Dissection and Preparation of Human Primary Fetal Ganglionic Eminence Tissue for Research and Clinical Application.- Robust Induction of DARPP32-Expressing GABAergic Striatal Neurons from Human Pluripotent Stem Cells.- Quality Assessment and Production of Human Cells for Clinical Use.
Erscheinungsdatum | 15.07.2019 |
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Reihe/Serie | Methods in Molecular Biology ; 1780 |
Zusatzinfo | 74 Illustrations, color; 37 Illustrations, black and white; XV, 642 p. 111 illus., 74 illus. in color. |
Verlagsort | Totowa, NJ |
Sprache | englisch |
Maße | 178 x 254 mm |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie |
Medizin / Pharmazie ► Studium | |
Naturwissenschaften ► Biologie ► Humanbiologie | |
Naturwissenschaften ► Biologie ► Zoologie | |
Schlagworte | Animal Models • Gene manipulation • Genetic Disease • Mutant huntingtin • Neurodegenerative Disease • Neuropathology |
ISBN-10 | 1-4939-9296-1 / 1493992961 |
ISBN-13 | 978-1-4939-9296-6 / 9781493992966 |
Zustand | Neuware |
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