Genomics of Pain and Co-Morbid Symptoms

Susan G. Dorsey, PhD RN FAAN, is a professor of nursing and chair in the Department of Pain and Translational Symptom Science, at the University of Maryland School of Nursing. She received her PhD from the University of Maryland, Baltimore and completed a postdoctoral fellowship at the National Cancer Institute in the Mouse Cancer Genetics Program. She holds secondary faculty appointments in the School Of Medicine Department of Anesthesiology and the School Of Dentistry's Neural & Pain Sciences Department. She co-directs the campus-wide Center to Advance Chronic Pain Research and serves as a Multiple Principal Investigator (MPI) for a newly awarded NINR-funded P30 Center, Omics Associated with Self-management Interventions for Symptoms (OASIS). In 2015, Dr. Dorsey was appointed as a translational research expert on the NCI Symptoms and Quality of Life Steering Committee and served as co-chair for the 2017 NCI Clinical Trials Planning Meeting for chemotherapy-induced peripheral neuropathy. Dr. Dorsey's translational program of research incorporates molecular, cellular and genetic/genomic methods to study chronic pain and cancer treatment-related neuropathic pain and related symptoms. Angela Starkweather is an acute care nurse practitioner and neuroscience nurse with 20 years of experience managing pain in acute and urgent care settings, who has devoted her career toward identifying the physiological mechanisms of persistent pain and developing personalized methods to mitigate pain and its detrimental consequences. The impact of her research has led to innovative self-management strategies for patients and families dealing with pain and other distressing symptoms. She has been funded by the National Institute of Nursing Research for the past 10 years and serves as the Director of the Center for Accelerating Precision Pain Self-Management at the University of Connecticut School of Nursing. She is past-Chair of the Genomic Nursing and Health Care Expert Panel of the American Academy of Nursing, and serves as an Ambassador of the Friends of the National Institute of Nursing Research, and standing member of the American Association of Neuroscience Nurses Clinical Practice Guidelines Board.

Chapter 1. Pain physiology (defining acute and chronic pain).- Chapter 2. Neurobiology of nociception (anatomy of ascending and descending systems).- Chapter 3. Genetics of pain and co-occuring symptoms.- Chapter 4. Sex differences and pain genomics.- Chapter 5. Systems biology/multi-omis approaches to pain and co-occuring symptoms.- Chapter 6. Pre-clinical rodent models of pain for genomics studies.- Chapter 7. Clinical models of experimental pain for genomics studies.- Chapter 8. Clinical pain genomics research.- Chapter 9. Pain phenotyping (methods, measures).- Chapter 10. Precision health and pain genomics.- Chapter 11. Exemplars of pain genomics studies (could be multiple chapters).- Chapter 12. Roadmap to translation of pain genomics.