Heat Shock Response

Lutz Nover (Autor)

Buch | Hardcover

536 Seiten

1991
Crc Press Inc (Verlag)
978-0-8493-4912-6 (ISBN)

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This book focuses on heat shock response-an active yet transient reprogramming of cellular activities to the needs of a stress protection mechanism designed to minimize heat damage and to optimize restoration of normal cellular activities after the stress period. This work places major emphasis on the structure and possible cellular functions of heat shock proteins as well as the analysis of heat shock protein-coding genes by transfection into homologous and heterologous expression systems. It also discusses heat shock effects on all levels of gene expression, on cell ultrastructure, and metabolic activities. This unique text is a must for all those who are involved with genetics, nucleic acids research, and cancer research.

Nover/, Lutz

INTRODUCTION: HISTORICAL ROOTS. STRESS PROTEINS and GENES. Inducers: Heat Shock and Chemical Stressors. Heat Shock Proteins. HSP-Coding Genes. The Glucose-Regulated Proteins (GRP). RNAs as Heat Shock Products. Gene Technology and Functional Analyses of hs Genes. The Heat Shock Transcription Factor. Control of HSP Synthesis. PROGRAMMING of CELLULAR ACTIVITIES. Chromatin Structure, Transcription and Pre-mRNP Processing. Synthesis and Degradation of Ribosomes. Translational Control. Modification and Degradation of Proteins. Recovery of Gene Expression. Heat Shock-Induced Changes of Cell Ultrastructure. Cell Cycle and DNA Synthesis. Intracellular Localization of Heat Shock Proteins. Induced Thermotolerance. Heat Shock Induced Developmental Effects. Hyperthermia and Virus Multiplication. Hyperthermic Treatment of Cancer.

Erscheint lt. Verlag	24.6.1991
Zusatzinfo	21 Tables, black and white; 16 Halftones, black and white
Verlagsort	Bosa Roca
Sprache	englisch
Maße	178 x 254 mm
Gewicht	1088 g
Themenwelt	Naturwissenschaften ► Biologie ► Zellbiologie
ISBN-10	0-8493-4912-5 / 0849349125
ISBN-13	978-0-8493-4912-6 / 9780849349126
Zustand	Neuware