Graphene Transistors for Bioelectronic Applications

This thesis investigates the science and technology of graphene solution-gated field-effect transistors (SGFETs) for applications in bioelectronics and biosensing. A detailed electrical characterization of transistors on rigid and flexible substrates shows good device performance and stability. Lipid membranes on graphene are characterized revealing monolayer formation. Rigid graphene SGFETs monitor lipid membrane formation and self-exchange of lipid membranes. Using flexible arrays of SGFETs action potentials from HL-1 cells are recorded in vitro. Further, the devices can be used to monitor brain activity in vivo, i.e. pre-epileptic activity and slow wave activity.