Multiscale Mechanobiology in Tissue Engineering

Damien Lacroix, INSIGNEO Institute for in silico Medicine, University of Sheffield, UKMarzia Brunelli, INSIGNEO Institute for in silico Medicine, University of Sheffield, UKCecile Perrault, INSIGNEO Institute for in silico Medicine, University of Sheffield, UKAdrien Baldit, INSIGNEO Institute for in silico Medicine, University of Sheffield, UKMaryam Shariatzadeh, INSIGNEO Institute for in silico Medicine, University of Sheffield, UKAna Campos Marin, INSIGNEO Institute for in silico Medicine, University of Sheffield, UKAndre Castro, INSIGNEO Institute for in silico Medicine, University of Sheffield, UKSara Barreto, INSIGNEO Institute for in silico Medicine, University of Sheffield, UK

A review of bioreactors and mechanical stimuli.- Multiscale simulation of bioreactor design and in vitro conditions.- Mechanical stimulation in a PCL additive manufacturing scaffold.- Towards a new approach to analyse quality control and morphometric variability in a scaffold.- Computational simulation of cell seeding in a tissue engineering scaffold.- Collagen gel cell encapsulation to study mechanotransduction.- Collagen gel cell encapsulation to study the effect of fluid flow on mechanotransduction.- Computational modeling of collagen hydrogel.- Mechanical load transfer at the cellular level.- Quantification of CSK mechanics and deformation in relation to cellular functioning.- The future of tissue engineering design for bioreactor stimulation.