Heat Shock Proteins in the Immune System

Robert J. Binder, Pramod K. Srivastava (Herausgeber)

Buch | Softcover

X, 185 Seiten

2018 | 1. Softcover reprint of the original 1st ed. 2018
Springer International Publishing (Verlag)
978-3-030-09862-9 (ISBN)

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Experts from around the world review the current field of the immunobiology of heat shock proteins, and provide a comprehensive account of how these molecules are spearheading efforts in the understanding of various pathways of the immune system. This one-stop resource contains numerous images to both help illustrate the research on heat shock proteins, and better clarify the field for the non-expert. Heat shock proteins (HSPs) were discovered in 1962 and were quickly recognized for their role in protecting cells from stress. Twenty years later, the immunogenicity of a select few HSPs was described, and for the past 30 years, these findings have been applied to numerous branches of immunology, including tumor immunology and immunosurveillance, immunotherapy, etiology of autoimmunity, immunotherapy of infectious diseases, and expression of innate receptors. While HSPs can be used to manipulate immune responses by exogenous administration, they appear to be involved in initiation of de novo immune responses to cancer and likely in the maintenance of immune homeostasis.

Pramod K. Srivastava, Department of Immunology, University of Connecticut Health CenterRobert J. Binder, Department of Immunology, University of Pittsburgh

Introduction and history.- Part I: Structure of the HSPs in relation to chaperoning peptides and proteins.- Chapter 1: Hsp70-subsrate interactions.- Chapter 2: Molecular Chaperone Inhibitors.- Part II: Exposure of HSPs to immune cells.- Chapter 3: Extracellular Heat Shock Proteins as Stress Communication Signals.- Part III: Regulation of immune responses by extracellular HSPs.- Chapter 4: The Heat Shock Protein-CD91 pathway and Tumor Immuno-surveillance.- Chapter 5: Bridging the gaps in the vaccine development: Avant-garde vaccine approach with secreted heat shock protein gp96-Ig.- Chapter 6: Regulation of the Extracellular Matrix by Heat Shock Proteins and Molecular Chaperones.- Chapter 7: Heat shock protein mediated T cell responses in pathogen infections.- Chapter 8: An ancestral immune surveillance system in the amphibian Xenopus connecting certain heat shock proteins with classical and nonclassical MHC class I molecules.- Chapter 9: Inhibition of HSPs for Enhanced Immunity.

Erscheinungsdatum	17.01.2019
Zusatzinfo	X, 185 p. 22 illus., 20 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	308 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
	Naturwissenschaften ► Biologie ► Biochemie
Schlagworte	Biological Pathways • Heat shock proteins • HSP inhibitors • immune system • Infectious Diseases • innate T cells • Vascular Normalization
ISBN-10	3-030-09862-1 / 3030098621
ISBN-13	978-3-030-09862-9 / 9783030098629
Zustand	Neuware