RNA Activation -

RNA Activation

Long-Cheng Li (Herausgeber)

Buch | Softcover
239 Seiten
2018 | Softcover reprint of the original 1st ed. 2017
Springer Verlag, Singapore
978-981-13-5102-0 (ISBN)
171,19 inkl. MwSt
This book offers an essential guide to RNA activation (RNAa), an emerging and fascinating new field. RNAa is a small RNA-guided and Argonaute-dependent gene regulation phenomenon in which promoter-targeted short double-stranded RNAs (dsRNAs) induce target gene expression at the transcriptional level. It occurs primarily in the nucleus and can be mediated by artificially designed short duplex RNAs that target regulatory sequences (e.g., promoters, genes’ 3’ termini and enhancers) and naturally occurring small RNAs (e.g., miRNAs and C. elegans 22G-RNAs).

With contributions from internationally respected RNA experts, this book provides comprehensive coverage of different RNAa mechanisms and a timely update on recent advances in RNAa research, with a focus on developing RNAa-based therapeutics. Special chapters are also devoted to the topics of gene activation induced by antisense oligonucleotides and the CRISPR system. As the first book to cover RNAa, it will be of interest to a wide audience, from scientists in academia and the pharmaceutical industry to clinicians who wish to further explore the biology of RNAa and related phenomena, so as to harness their full potential for use in biotechnology and drug development.

Dr. Long-Cheng Li is a professor at Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

PART I  Exogenous RNAa.- PART II Endogenous RNAa.- PART III  RNA activation guided by other small RNAs.- PART IV Developing RNAa-based therapeutics.- 

Erscheint lt. Verlag 9.12.2018
Reihe/Serie Advances in Experimental Medicine and Biology ; 983
Zusatzinfo 38 Illustrations, color; 7 Illustrations, black and white; XIV, 239 p. 45 illus., 38 illus. in color.
Verlagsort Singapore
Sprache englisch
Maße 155 x 235 mm
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete
Studium 2. Studienabschnitt (Klinik) Humangenetik
Naturwissenschaften Biologie Biochemie
Naturwissenschaften Biologie Genetik / Molekularbiologie
Naturwissenschaften Biologie Zellbiologie
Schlagworte epigenetics • Genome editing • RNA Activation/ RNAa • RNA Interference • RNA Sequencing • small RNA
ISBN-10 981-13-5102-3 / 9811351023
ISBN-13 978-981-13-5102-0 / 9789811351020
Zustand Neuware
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