Substance P and Neurokinins

I. Synthesis; Metabolism; Molecular Biology; New Neurokinins.- 1. Substance P and Neurokinins.- 2. Cloning and Expression of Rat and Human Tachykinin Genes.- 3. Structure, Expression and Regulation of the Rat Preprotachykinin I Gene.- 4. Striatonigral Tachykinin Biosynthesis I. Effect of the Dopamine Antagonist Haloperidol.- 5. Thyroid Hormone Regulates Tachykinin Gene Expression in Rat Anterior Pituitary.- 6. Phylogeny of the Tachykinins.- 7. Metabolism of Tachykinins by Cell-Surface Peptidases.- 8. Structure and Post-Translational Processing of the Preprotachykinins.- 9. Substance P Content in and Capsaicin-Evoked Release from Dissociated Cultures of Rat Nodose Ganglion (Vagal Sensory) Neurons.- 10. Biosynthesis of Substance P and Neurokinin A in the Enteric Nervous System.- 11. Striatonigral Tachykinin Biosynthesis.- 12. Substance P Precursor Studies in Carcinoid Tumours.- 13. Chronic Neuroleptic Administration Reduces Striatal Substance P mRNA and the Localization of Substance P mRNA in Rat Brain by In Situ Hybridization.- II. Binding Assays And Conformational Studies.- 14. Multiple Receptors and Binding Sites for Tachykinins.- 15. Multiple Tachykinin Binding Sites in Rat Brain and Peripheral Tissues.- 16. 3H-Neurokinin B and [125I]-Bolton Hunter Eledoison Label Identical Tachykinin Binding Sites in the Rat Brain.- 17. Characterization of Tachykinin Receptor Subtypes Using Selective Ligands.- 18. Characterization of Binding of [125I] Iodohistidyl-Substance K to Tachykinin K-Sites in Hamster Bladder.- 19. Endothelial-Dependent Binding of [125I]-Bolton-Hunter Substance P in Blood Vessels.- 20. Tachykinin-Induced Phosphatidylinositol Turnover in Hamster Urinary Bladder.- 21. Conformationally Restricted Analogues of Substance P.- 22. Toward the Bioactive Conformation of Tachykinins?.- 23. Evidence for the Zipper Model in Tachykinin Receptor Binding.- 24. Effects of Substance P on the Binding of Ligands to Nicotinic Acetylcholine Receptors on Torpedo Electroplaque Membranes.- 25. Interaction of Analgesic Capsaicin Analogs with Substance P Receptors.- 26. Tachykinins and Phosphatidyl Inositol Turnover in Rat Brain.- 27. Tyr8-Substance P Binding Study on a Plasma Membrane from Dog Ileum Smooth Muscle.- 28. Multiple Tachykinin Binding Sites in Hamster, Guinea-Pig and Rat Bladder.- 29. Tachykinin P-type Binding Sites in Dog Kidney.- 30. Substance P Binding Sites in Guinea-Pig Enteric Ganglia.- 31. Autoradiographic Localization of Substance P Binding Sites in Guinea-Pig Respiratory Tract.- 32. [125I]-Bolton Hunter Substance P Specific Binding Sites on Cortical Astrocytes from New Born Mouse in Primary Culture.- 33. Autoradiographic Distribution of Binding Sites for Iodinated Tachykinins in the Rat Central Nervous System.- 34. Neurokinin Receptors in Human Brain.- III Biological Assays; Tachykinin Antagonists.- 35. Receptors for Neurokinins in Peripheral Organs.- 36. Substance-P-Induced Desensitization in Canine Cephalic Arteries is not Mimicked by Substance K, Physalaemin, or Kassinin.- 37. Multiple Neurokinin Receptors in the Rat Lower Urinary Tract.- 38. Structure-Activity Relationships of Neurokinin A and B.- 39. Tachykinin Antagonists with Cyclic Structures.- 40. Electrical and Mechanical Responses of Vascular Muscle to Tachykinis.- 41. [D-Pro2, D-Trp6,8, Nle10] -Neurokinin B: Pharmacological Profile of a Novel Neurokinin Antagonist.- 42. Isolated Arterial and Venous Vessels as Selective Pharmacological Preparations for Neurokinins.- 43. Neurokinin Fragments and Analogues as Selective Activators of Receptors.- 44. Mammalian Neurokinins: Structure-Activity Study of the N- and C-Terminals.- 45. Neurokinin Receptor Mechanisms in Smooth Muscle.- 46. Neurokinin Receptors in Guinea Pig Intestinal Muscle.- 47. Multiple Neurokinin Receptors in the Guinea Pig Ileum.- 48. Synthesis and Biological Activity of Agonists for the Neuronal Tachykinin Receptor in Guinea Pig Ileum.- 49. Tachykinin Activation of Muscarinic Inhibition in Canine Small Intestine is Substance P in Nature.- 50. Evidence for Three Distinct Peripheral Neurokinin Receptors Using a Putative Neurokinin B Antagonist.- 51. Identification and Localization of Substance P Receptors on the Endothelium of the Pig Coronary Artery.- 52. Activity of the C-Terminal Part in Tachykinins on Guinea Pig Ileum and Trachea Preparations.- 53. Relative Vasodilatory Potencies of Substance P, Deca-Substance P. and Nona-Substance P in the Canine Forelimb.- 54. Hemodynamic Actions of Substance P in Anesthetized Rats.- 55. The Effect of Substance P Antiserum on Responses of Guinea-Pig Isolated Ileum to Substance P and Acetylcholine.- 56. Antibodies as Tools for Studying Tachykinins and Their Receptors.- 57. Characterization of Spinal Actions of Ten Substance P Analogs.- 58. Substance P Antagonists and Analgesia: Do They or Don't They?.- 59. Substance P in Human Spermatozoa and Modulation of Sperm Motility by Substance P and Its Antagonists.- IV Distribution and Role in Peripheral Tissues.- 60. Effector Roles of Substance P in Peripheral Branches of Sensory Neurons.- 61. Tachykinins and Gastrointestinal Propulsion in the Rat In Vivo.- 62. Substance P Effects on the Long-Term Regulation of Adrenal Catecholamine Levels.- 63. Effects of Substance P and Calcitonin Gene-Related Peptide on Skeletal Muscle Microcirculation.- 64. Substance P Effect on the Secretory Process in Rat Parotid Gland.- 65. Effects of Substance P on Blood Flow of the Dental Pulp in Dogs.- 66. Influence of Anesthesia and Atropine on Plasma Extravasation Induced by Mammalian Tachykinins in the Rat.- 67. Tachykinin-Induced Plasma Extravasation in Rat Skin is Mediated Through the SP-P Receptor.- 68. Peptides as Promoters of Paracellular Permeability: A Novel Role For Tachykinins?.- 69. Release of Substance P from Isolated Guinea Pig Heart.- 70. Effects of Tachykinins on the Rat Stomach In Vivo and In Vitro.- 71. Endoluminal Substance P is Released by a Meal.- 72. Effect of Substance P and Neurokinins on the Endocrine Secretion of the Pancreas and Stomach.- 73. Development of the Substance P-Like Immunoreactive Innervation of the Mesenteric Vascular Bed in Normotensive and Hypertensive Rats.- 74. Increase of Plasma Substance P- and Neurokinin A-Like Immunoreactivity During Carcinoid Flushing.- 75. HPLC and Immunohistochemical Characterization of Substance P-Like Immunoreactivity in a Human Pheochromocytoma.- 76. Role of Capsaicin-Sensitive Primary Afferent Nerves in the Neuroendocrine Copulation Reflex.- 77. Substance K-, Substance P-, and Calcitonin Gene-Related Peptide-Immunorective Nerves in Female Reproductive Organs.- 78. Substance P- and Somatostatin-Like Immunoreactivity in Maternal and in Umbilical Cord Plasma and in Amniotic Fluid.- V. Roles Associated With Sensory Neurons.- 79. Effects of Spantide on Reflexes of Slow Time Courses in Isolated Rat Spinal Cord.- 80. A Depressant Action of Substance P on Spinal Nociceptive Neurons in the Rat and Cat.- 81. Physalaemin, Substance P and Neurokinin A Potentiate Purine-Induced Depression of Spinal Dorsal Horn Neurones in the Cat.- 82. Multiple Tachykinins and Calcitonin Gene-Related Peptide (CGRP) in Capsaicin-Sensitive Nerves of Sympathetic Ganglia.- 83. Intrathecal Substance P Produces a Long-Term Inhibition of the Spinal Analgesic Effect of Noradrenaline.- 84. Pharmacological Modulation of Antidromic Vasodilatation Measured by Laser Doppler Flowmetry.- 85. Capsaicin Sensitive Afferent Neurons Involved in Neuroendocrine Regulations.- 86. Sensory C Fiber Mediate Mucociliary Responses to Airway Irritants.- 87. Substance P Modulates Cholinergic Regulation of the Nicotinic Acetylcholine Receptor of PC12 Cells.- 88. Evidence of ACTH-Adrenal and Chronic Stress-Induced Down Regulation of Substance P in the Sensory Vagus Nerve.- 89. Substance P and Hypoxic Excitation of the Carotid Body.- 90. Immunochemical Studies on Substance P Release from Muscularis Mucosa of Opossum Esophagus.- 91. Substance P-Immunoreactive Fibers in the Trigeminal Sensory Nuclei of Pit Vipers, Trimeresurus Flavoviridis.- 92. Miotic Effect of Echothiophate Iodide in Humans: Possible Role of Iris Substance P.- 93. The Effects of Neurokinin A and Calcitonin Gene-Related Peptide on Mucociliary Activity.- 94. Neurokinin A Excites Nociceptive and Non-Nociceptive Dorsal Horn Neurones in the Cat Spinal Cord.- 95. Modality Specific Analgesia Produced by Intrathecal Anti-Substance P Antibody.- 96. A Quantitative Study of Substance P and Cholecystokinin Coexistence in Primary Afferent Axonal Varicosities in the Rat Spinal Cord.- 97. Sciatic Nerve Stimulation and Substance P Release from Posterior Pituitary Lobe (PPL) in Rats.- 98. Neurokinin A as a Transmitter of Primary Afferents Involved in Thermal Nociception.- VI. Distribution and Roles in the Central Nervous System.- 99. Reflections on Substance P and Some Related Peptides.- 100. Regional Distribution of Neurokinin A and Substance P in the Rat Central Nervous System.- 101. Regulation of Substance P Immunoreactivity in GABA Neurons of Monkey Visual Cortex by Sensory Deprivation.- 102. Interactions Between Substance P and Nicotinic Acetylcholine Receptors in Pain Control Mechanisms in the Rat.- 103. Central Modulation of Blood Pressure by N- and C-Terminal Fragments of Substance P.- 104. Effects of Tachykinins on Dopamine Release in the Striatum: In Vitro and In Vivo Studies.- 105. Immunocytochemical Localization of Substance P-Like Immunoreactivity in the Human Hypothalamus.- 106. Substance P and Somatostatin-Like Immunoreactivities in Synaptic Glomeruli of the Rat Substantia Gelatinosa, as Revealed by Bi-Specific Monoclonal Antibodies.- 107. A Sex Difference in the Pattern of Substance P-Like Immunoreactivity in the Bed Nucleus of the Stria Terminalis.- 108. Suppression of Noradrenaline-Induced Ovulation by Administration of Substance P into the Third Cerebral Ventricle in Pseudo-Pregnant Rats.- 109. Spinal Actions of Substance P on Cardiovascular Responses in the Rat.- 110. Evidence for at Least Two Tachykinin Receptor Subtypes in the Mammalian Spinal Cord.- 111. Spinal and Supraspinal Substance P Antinociception: Synergistic Interaction.- 112. Substance P Empty Neuron: A Conceptualization of Organic and Functional Deafferentation Syndromes.- 113. Excitatory Effects of Substance P and Related Peptides on Oxytocin-Sensitive Non-Pyramidal Neurones in Rat Hippocampus.- 114. Electrophysiological Correlates of Bradykinin and Other Neuropeptides in Developing Rat Cerebral Cortex.- 115. Effects of an Amino-Terminal Fragment of Substance P on Brain Dopamine and Serotonin Metabolism.- 116. Effect of Carbamazepine on Substance P Content in the Rat Brain.- 117. Release of Substance P, Acetylcholine and Methionine Enkephalin from Mouse Cerebral Slices: Effects of Nicotine.- 118. Different Functional Roles for Substance P and Dynorphin in the Striato-Nigral Pathways of the Rat.- 119. Striato-Nigral Tachykinin Neurons and Influence from Striatal Dopamine and GABA.- 120. Substance P, Thyrotropin-Releasing Hormone, and Serotonin Neurons Sprout in Cervical Ventral Horn of the Wobbler Mouse, a Model for Motoneuron Disease.- 121. Intra-Raphe Substance P5-11 but Not Muscimol-Induced Hyperactivity is Mediated by Serotonin Neurons.- 122. Heterogeneity of Central and Peripheral Tachykinin Binding Sites.- 123. Research on Tachykinins: Clinical Trends.- 124. A Network of Defense.