Emerging Fluorinated Motifs

Dominique Cahard, PhD, is Director of Research at the French National Center for Scientific Research, CNRS. His current research interests concern innovative methodologies for asymmetric synthesis of fluorinated molecules and the synthesis of fluorinated biomolecules. Jun-An Ma, PhD, is a Full Professor of organic chemistry and the Vice Dean of the School of Science at Tianjin University. His current research efforts are focused on organofluorine chemistry and catalytic asymmetric synthesis.

Volume I

Part I: Carbon-Linked Fluorine-Containing Motifs
Chapter 1: Difluoromethylation and Difluoroalkylation of (Hetero)Arenes. Access to Ar(Het)-CF2H and Ar(Het)-CF2R
Chapter 2: Difluoromethylation and Difluoroalkylation of Aliphatic Unsaturated C=C, CC,-NC Bonds
Chapter 3: Difluoromethylation and Difluoroalkylation at Csp3 Centres, C=O , C=C, and C=N Bonds
Chapter 4: Monofluoromethylation Reactions of Aliphatic Substrates and (Hetero)Arenes
Chapter 5: Synthesis of gem-Difluorocyclopropanes

Part II: Oxygen-Linked Fluorine-Containing Motifs
Chapter 6: Indirect Construction of the OCF3 Motif
Chapter 7: Reagents for Direct Trifluoromethoxylation
Chapter 8: Direct Trifluoromethoxylation of Aromatics and Heteroaromatics
Chapter 9: Direct Trifluoromethoxylation of Aliphatic Compounds
Chapter 10: Extension to the Construction of ORf Motifs (OCF2H, OCFH2, OCH2CF3, OCFHCH3)

Volume II
Part III: Sulfur-Linked Fluorine-Containing Motifs
Chapter 11: Indirect Trifluoromethylthiolation Methods
Chapter 12: Reagents for Direct Trifluoromethylthiolation
Chapter 13: Trifluoromethylthiolation of Aromatics and Heteroaromatic Compounds
Chapter 14: Synthesis of Trifluoromethylthiolated Alkenes and Alkynes
Chapter 15: Direct Trifluoromethylthiolation toward C(sp3)-SCF3 Compounds
Chapter 16: Extension to the SCF2H, SCH2F, and SCF2R motifs (R = PO(OEt)2, CO2R, Rf)
Chapter 17: Synthesis and Applications of Fluorinated Sulfoxides (RSORf) and Sulfones (RSO2Rf)
Chapter 18: Pentafluorosulfanylation of Aromatics and Heteroaromatics
Chapter19: Pentafluorosulfanylation of Aliphatic Substrates
Chapter 20: Extension to SF4CF3 and SF4FG Groups
Chapter 21: Properties & applications of sulfur(VI) fluorides
Chapter 22: Construction S-Rf Sulfilimines and S-Rf Sulfoximines

Part IV: Selenium-Linked Fluorine-Containing Motifs
Chapter 23: When Fluorine Meets Selenium

Part V: Nitrogen-Linked Fluorine-Containing Motifs
Chapter 24: Construction of N-CF2H, N-CF3, N-CH2CF3 Motifs

Part VI: Phosphorus-Linked Fluorine-Containing Motifs
Chapter 25: Synthesis and Applications of P-Rf-Containing Molecules