Activity-Based Protein Profiling

Benjamin F. Cravatt, Ph.D. Department of Chemistry The Scripps Research Institute La Jolla, CA, USA cravatt@scripps.edu Ku-Lung Hsu Ph.D. University of Virginia School of Medicine Department of Chemistry Charlottesville, VA, USA kh4ch@virginia.edu Eranthie Weerapana Ph.D. Boston College Merkert Chemistry Chestnut Hill, MA, USA eranthie@bc.edu

Activity-based protein profiling - enabling multimodal functional studies of microbial communities.- Activity-Based Protein Profiling Methods to Study Bacteria: The Power of Small-Molecule Electrophiles.- Opportunities and Challenges in Activity-Based Protein Profiling of Mycobacteria.- Activity-Based Protein Profiling at the Host-Pathogen Interface.- Chemical Proteomic Profiling of Protein Fatty-Acylation in Microbial Pathogens.- How to Target Viral and Bacterial Effector Proteins Interfering with Ubiquitin Signaling.- ABPP and Host-Virus Interactions.- Activity-Based Protein Profiling for the Study of Parasite Biology.- Deciphering T Cell Immunometabolism with Activity-Based Protein Profiling.- Small-Molecule Inhibitors of PARPs: From Tools for Investigating ADP-Ribosylation to Therapeutics.- Development of Activity-Based Proteomic Probes for Protein Citrullination.- Recent Advances in Activity-Based Protein Profiling of Proteases.- Opportunities for Lipid-Based Probes in the Field of Immunology.- Activity-Based Protein Profiling of Non-ribosomal Peptide Synthetases.- Target Identification of Bioactive Covalently Acting Natural Products.- Applications of Reactive Cysteine Profiling.