GHRH, GH, and IGF-I

I. Overview of Physiology of the GHRH-Somatostatin-GH-IGF-I Axis.- 1. Physiology of the Growth Hormone Releasing Hormone-Somatostatin-Growth Hormone-Insulin-Like Growth Factor I Axis.- 2. Role of Somatostatin in the Regulation of Growth Hormone Secretion.- 3. Growth Hormone Releasing Hormone and Growth Hormone Releasing Peptides.- 4. GH Binding Protein, GH Receptors, and Domains Involved in Signal Transduction.- 5. Insulin-Like Growth Factors During Development.- II. Effects of Recombinant Human GH and/or IGF-I in Catabolic Illness.- 6. Anabolic Effects of Recombinant Human Growth Hormone and Insulin-Like Growth Factor I in Human Disease.- 7. Growth Hormone in Children with Chronic Renal Disease: Some Metabolic Considerations.- 8. Growth Hormone: The Visible Difference in Burn Care.- 9. Effects of Recombinant Human Growth Hormone on Body Composition and Metabolism in HIV-Associated Wasting.- 10. Administration of Growth Hormone as an Adjunct to Nutritional Support in Critical Illness.- 11. Strategies for the Use of Recombinant Human Growth Hormone and Insulin-Like Growth Factor I in Amyotrophic Lateral Sclerosis.- III. Contemporary Issues in Growth and Development.- 12. Contemporary Issues in Growth and Development: An Overview.- 13. Use of Recombinant IGF-I in Syndromes of GH Insensitivity.- 14. Use of Growth Hormone in Non-Growth-Hormone-Deficient Children: Physiologic, Pharmacologic, and Ethical Issues.- 15. Growth Hormone Treatment of Nonelderly Adults with GH Deficiency.- IV. Effects of rhGH and IGF-I on Intermediary and Bone Metabolism.- 16. Overview of Growth Hormone and IGF-I Effects on Intermediary Metabolism and Bone.- 17. Effects of rhGH on Glucose, Lipid, and Amino Acid Metabolism.- 18. Metabolic Effects of IGF-I: Implications for the Therapy of Diabetes Mellitus.- 19. Modulation of Responses to GH and IGF-I by Nutritional Variables.- 20. Growth Hormone Effects on the Adult Skeleton.- 21. Insulin-Like Growth Factors and Skeletal Remodeling.- V. Use of GHRH, rhGH, and rhIGF-I in Aging.- 22. Growth Hormone and Aging: A Brief Review.- 23. Potential Benefits and Risks in Treating the Hyposomatomedinemia and Hypogonadism of Elderly Men.- 24. Effects of Growth Hormone Releasing Hormone Administration in Healthy Aging Men.- 25. Effects of Recombinant Human Insulin-Like Growth Factor I in Aging.- 26. Growth Hormone and Immune Function in the Elderly.- 27. Treatment with Growth Hormone: Focus on Specificity with a View to the Future.- Author Index.