Unraveling the Exposome (eBook)

Dr. Sonia Dagnino is currently a Marie Sklodowska-Curie Research Fellow at the Epidemiology and Biostatistics Department at Imperial College London, School of Public Health. Dr. Sonia Dagnino's research is focused on the development of new methodologies for the understanding of the exposome and its implications for human health. Dr. Dagnino is actively engaged in several research projects on the exposome worldwide and has an extensive expertise in this field.Dr. Macherone serves as a Senior Scientist with Agilent Technologies and a Visiting Professor at the Johns Hopkins School of Medicine. He is also on the faculty of P2i (Preconception 2 infancy) with a focus of providing “women and couples tools to improve their odds of healthy, full-term pregnancies, thus reducing the incidence of serious, chronic disorders among their children”. Dr. Macherone is an expert in exposomics and is actively engaged in several publicly or privately funded exposomics investigations. 

Part1. The utility of the Exposome Paradigm.- Chapter1. Using Exposomics to assess cumulative risks from multiple environmental stressors.- Chapter2. Sequencing the Public Health Exosome.- Chapter3. The US Military and the Exposome.- Chapter4. Framing Fetal and Early Life Exposome within Epidemiology.- Part2. Measuring the internal exposome.- Chapter5. Epigenetics and the exposome.- Chapter6. Metabonomics.- Chapter7. Transcriptomics within the exposome paradigm.- Part3. Measuring sources of exposure.- Chapter8. The food exposome.- Chapter9. The Dust Exposome.- Chapter10. From the Outside In; Integrating External Exposures into the Exposome Concept.- Part4. ata analysis for the exposome.- Chapter11. Statistical models to explore the exposome: from OMICs profiling to ‘mechanome’ characterization.- Chapter12. Data-driven Analytics and Informatics to Con-nect the Exposome with Phenotype in Larger Scale.- Part5. xposome characterization around the globe.-Chapter13. HERCULES: an academic center to support exposome research.- Chapter14. Exposomics: meet-in-the-middle and network perturbation.- Chapter15. Building an Early Life Exposome by Integrating Multiple Birth Cohorts: HELIX.- Chapter16. The HEALS project.- Part6. Conclusion.- Chapter17. Unravelling the exposome: conclusions and thoughts for the future.