Gene Therapy of Cancer

Genetic and immunologic targets for gene therapy - tumour suppressor genes as targets for cancer gene therapy; characterization of specific genetic alterations in cancer cells; immunologic targets for the gene therapy of cancer; vectors and engineered products for cancer therapy; retroviral vector design for cancer gene therapy; non-infectious gene transfer and expression systems for cancer gene therapy; parvovirus vectors for the gene therapy of cancer; antibody-targeted gene therapy; cytokine gene therapy using in situ injection of vaccinia virus vectors; ribazymes in cancer gene therapy; manipulating drug effects through gene therapy - in situ use of suicide genes for cancer therapy; transfer of drug resistance genes into haematopoietic progenitors; cytosine deaminase as a suicide gene in cancer therapy; preemptive and therapeutic uses of suicide genes for cancer and leukaemia; targeting oncogenes and growth for gene therapy - gene therapy in vivo of hepatocellular and liver-metastatic colorectal cancer; antisense strategies in the treatment of leukemias; selective replicating viruses as therapeutic against cancer; molecular vaccine strategies for cancer oncogene products as tumours-specific antigens for activation of T-lymphocyte-mediated immunity; polynucleotide-mediated immunization; theory of cancer; DNA and dendritic cell-based immunization against cancer; genetically modified cells for immunization - engineering cellular cancer vaccines - gene and protein transfer options; cancer gene therapy by direct gene transfer of plasmid DNA in cationic lipids; ex vivo and in vivo cytoreductive gene therapy for urologic cancers - translation of molecular pharmacology to clinical pharmacology; applications for gene transfer in the adoptive immunotherapy of cancer; cytokine gene therapy of cancer; genetically modified effector cells for immune based immunotherapy -the use of genetically modified haematopoietic stem cells for cancer therapy; novel artificial tumour-specific killer cell and intrabody approaches for cancer therapy.