Medicinal Chemistry

An Introduction to Drug-Receptor Interactions;

Signal Transduction and Second Messengers;

Enzyme Inhibitors;

The Biological Evaluation of New Compounds;

Pharmacokinetics;

Drug Metabolism;

Physicochemical Properties and Drug Design;

Quantitative Structure-Activity Relationships;

Considerations for the Use of Computational Chemistry Techniques by Medicinal Chemists;

`Patent Medicine';

Molecular Biology - A New Route to Drug Discovery;

Devising a Research Strategy;

Past Approaches to Discovering New Drugs as Medicines;

Bioisosteres, Conformational Restriction, and Pro-drugs: Approaches to Lead Optimisation - Case History: An Example of a Conformational Restriction Approach;

The Design and Synthesis of Selective Protein Kinase C Inhibitors;

Discovery of 1069C - A Novel Synthetic Antitumour Agent with Low Cross-resistance Potential;

The Design and Biological Properties of `Dipeptoid' Antagonists;

Migraine Therapy - From Serotonin to Sumatriptan;

Drug Development;

Appendices;

Subject Index.