Vascular Ion Channels in Physiology and Disease

Alex Dopico, PhD, MD, is Chair of Pharmacology and Distinguished Professor at the University of Tennessee Health Science Center, Memphis, Tennessee. His research interest focuses on the molecular interactions between small amphiphilic ligands, such as alcohol, and oligomeric ion channel proteins in excitable tissues, with a particular focus on cerebral artery smooth muscle. Emphasis is put on determining site(s) of action and ion channel gating mechanisms targeted by the amphiphiles, role of membrane lipid microenvironment in regulating ligand-ion channel interaction, and consequences of such interaction on tissue and organ function. Dr. Dopico currently holds a Merit Award from NIAAA, and also served as editor of the book Methods in Membrane Lipids published by Humana in 2007. Irena Levitan, PhD, is a Professor of Medicine and Adjunct Professor of Pharmacology and Bioengineering at the University of Illinois at Chicago. Her current research interests focus on cholesterol regulation of ion channels and cellular biomechanics. She was named a Guyton Distinguished Lecturer by the Association of Chairs of Departments of Physiology for her quantitative and biophysical work on cholesterol modulation of ion channels and how this can affect integrated organ function. She also served as editor of the book Cholesterol Regulation of Ion Channels and Receptors, published by Wiley in 2012.

lt;b>ForewordMark T. Nelson
I. Ion channel regulation of vascular tone and blood flow.  Changes with hypertension.
I.1. Endothelial cells
I.1.1. Endothelial cell ion channel expression and function in arterioles and resistance arteriesWilliam F. Jackson
I.1.2. Contribution and Regulation of Calcium channels in Endothelial CellsKwong Tai Cheng, Avia Rosenhouse-Dantsker, and Asrar B. Malik   
I.1.3. Mitochondrial depolarization in endothelial and other vascular cells and their role in the regulation of cerebral vascular toneDavid W. Busija, Ibolya Rutkai, and Prasad V. Katakam
I.1.4. Ion channels in Hypertension and Control of Blood Flow: Electrical conduction along endothelium of resistance arteriesErik J. Behringer and Steven S. Segal
I.1.5. Ca2+/calmodulin-gated small- and intermediate-conductance KCa channels in cardiovascular regulation: Targets for novel pharmacological treatmentsRalf Köhler. Aida Olivan-Viguera
I.2. Smooth Muscle Cell
I.2.1. Regional Variation in Arterial Myogenic Responsiveness - Links To Potassium Channel Diversity/FunctionMichael A. Hill, Yan Yang, Zahra Nourian, Barry D. Kyle, Kwangseok Hong and Andrew P. Braun
I.2.2. Ion Channel Trafficking and Control of Arterial ContractilityM. Dennis Leo and Jonathan H. Jaggar
I.2.3. Abnormalities of Vascular Ion Channels during HypertensionI.2.4. Kv7 Potassium Channels as Therapeutic Targets in Cerebral VasospasmBharath K. Mani, Lyubov I. Brueggemann, Sarkis Morales-Vidal, Christopher M. Loftus, and Kenneth L. Byron
I.2.5. Lysosomal Transient Receptor Potential Mucolipin (TRPML) Channels in Vascular Regulation and Diseases Fan Zhang, Pin-Lan Li
II. Ion channels in the regulation of cell proliferation, remodeling, hypertrophy and angiogenesis
II.1. Calcium Mobilization via Intracellular Ion Channels, Store Organization and Mitochondria in Smooth MuscleJohn G. McCarron, Susan Chalmers, Calum Wilson & Mairi E. Sandison
II.2. Role of mechanosensitive TRP channels in Abnormal Vasculature of Tumors Holly C. Cappelli, Roslin J. Thoppil, Ravi K. Adapala, J. Gary Meszaros, Sailaja Paruchuri, and Charles K. Thodeti
II.3. TRPC and Orai channels in store-operated calcium entry and vascular remodeling
David J Beech, Jing Li, Lynn McKeown, and Hollie L Appleby
II.4. Smooth muscle cell ion channels in pulmonary arterial hypertension: pathogenic role in pulmonary vasoconstriction and vascular remodelingRamon J. Ayon, Haiyang Tang, Ruby A. Fernandez, Ayako Makino, and Jason X.-J. Yuan
III. Ion channel regulation by lipids and channel modifications in metabolic disease
III.1. Physiological roles and cholesterol sensitivity of endothelial inwardly-rectifying K+ channels: specific cholesterol-protein interactions through non annular binding sites Irena Levitan, Sang Joon Ahn, Ibra Fancher, Avia Rosenhouse-Dantsker
III.2. Membrane lipids and modulation of vascular smooth muscle ion channelsAlex M. Dopico, Anna N. Bukiya and Guruprasad Kuntamallappanavar
III.3. Transient receptor potential channels in metabolic syndrome-induced coronary artery diseaseStacey L. Dineen, Zachary P. Neeb, Alexander G. Obukhov, and Michael Sturek
III.4. Mitochondrial ion channels in metabolic diseaseAaron H Truong, Saravanakumar Murugesan, Katia D Youssef, and Ayako Makino
Index