Regulation of Cytokine Gene Expression in Immunity and Diseases

Buch | Softcover

225 Seiten

2018 | Softcover reprint of the original 1st ed. 2016
Springer (Verlag)
978-94-024-1436-3 (ISBN)

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This book explores the major cytokines, such as IL-1 and IFN-γ, with respect to the regulation of their gene expression and protein production in specific immune cell types. It discusses both healthy physiological settings and in pathological situations in which the expression of some cytokines could be dysregulated, resulting in either immunodeficiency or exacerbated inflammatory sequelae in animal models as well as in human patients. Cytokines are important regulators of immune responses that require the highly coordinated participation and communication of multiple cell types. The expression of cytokines by various producer cell types is therefore carefully regulated in response to environmental cues at multiple levels: transcription, translation and posttranslational modification. Presentingcutting-edge advances in our understanding of the regulation of cytokine expression, this book is a valuable resource for anyone involved or interested in immune regulation.

Dr. Xiaojing Ma is a professor from Department of Microbiology and Immunology, Weill Cornell Medical College, USA. He is also the chair professor and associate dean of School of Life Sciences and Biotechnology, Shanghai Jiao Tong University. He serves as the associate editor of The Journal of Immunology, and is in the editorial board of several international journals, such as The Journal of Experimental Medicine, Annual Review of Biomedical Science and Cellular and Molecular Immunology. His research focuses on molecular regulation of cytokine gene expression and their immunological activities in inflammatory diseases, and he has published more than 80 research articles on top journals in this field.

Regulation of IFN-γ expression.- Regulation of The interleukin-1 family.- Regulation of IL-4 Expression in Immunity and Diseases.- Regulation of IL-6 in immunity and diseases.- Regulation of Interleukin-10 Expression.- Regulation of Interleukin-12 Production in Antigen-Presenting Cells.- Regulation of Interleukin-17 production.- Regulation of interleukin-23 expression in health and disease.- Regulation and immune function of IL-27.- The immunobiology of Interleukin-35 and its regulation and gene expression

Erscheinungsdatum	18.08.2018
Reihe/Serie	Advances in Experimental Medicine and Biology ; 941
Zusatzinfo	22 Illustrations, color; 1 Illustrations, black and white; VIII, 225 p. 23 illus., 22 illus. in color.
Verlagsort	Dordrecht
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Naturwissenschaften ► Biologie ► Zellbiologie
Schlagworte	autoimmunity • Cytokine • Epigenetic regulation • gene expression • immunity • Infection
ISBN-10	94-024-1436-3 / 9402414363
ISBN-13	978-94-024-1436-3 / 9789402414363
Zustand	Neuware