How to Overcome the Antibiotic Crisis

Prof. Dr. Marc Stadler and Prof. Dr. Petra DerschHelmholtz Centre for Infection Research, Braunschweig, Germany

Tackling threats and future problems of multidrug-resistant bacteria.-Emergence and spread of antimicrobial resistance: recent insights from bacterial population genomics.- Epidemiology of Staphylococcus aureus nasal carriage patterns in the community.- Diagnostics and resistance profiling of bacterial pathogens.- Use of antibiotics and antimicrobial resistance in veterinary medicine as exemplified by the swine pathogen Streptococcus suis.-Antibiotics and the intestinal microbiome: individual responses, resilience of the ecosystem and the susceptibility to infections.- Anti-virulence strategies to target bacterial infections.- Strategies to block bacterial pathogenesis by interference with motility and chemotaxis.- New horizons in the development of novel needle-free immunization strategies to increase vaccination efficacy.- History of antibiotics research.- Actinobacteria and Myxobacteria - Two of the most important bacterial resources for novel antibiotics.- Exploitation of fungal biodiversity for discovery of novel antibiotics.- Strategies for the discovery and development of new antibiotics from natural products: Three Case Studies.- New structural templates for clinically validated and novel targets in antimicrobial drug research and development.- Synthesis of antibiotics.- Antibiotics clinical development and pipeline.- Anti-infectives in drug delivery-overcoming the Gram-negative bacterial cell envelope.