Physics at the Biomolecular Interface

Ariel Fernández (born Ariel Fernández Stigliano) is an Argentine-American physical chemist and mathematician. He obtained his Ph. D. degree in Chemical Physics from Yale University in record time. He held the Karl F. Hasselmann Endowed Chair Professorship in Engineering at Rice University and was a Professor of Bioengineering until his retirement in 2012. To date, he has published over 350 scientific papers in professional journals including Physical Review Letters, PNAS, Nature, Genome Research and Genome Biology. Ariel Fernandez has also published two books: "Transformative Concepts for Drug Design" (2010) and "Biomolecular Interfaces" (2015), both with Springer, and holds two patents (US. 8,466,154 and 9,051,387) on biotechnological innovations. He is currently involved in research and entrepreneurial activities at various consultancy firms.

Chapter 1 Interfacial Physics for Water in Biology.- Chapter 2 Dielectric Structure of Aqueous Interfaces: From Classical non-Debye Electrostatics to a Quantum Theory of Interfacial Tension.- Chapter 3 Solution to the Protein Folding Problem.- Chapter 4  Epistructural Dynamics of Biological Water.- Chapter 5 Dehydron-Rich Proteins in the Order-Disorder Twilight Zone.- Chapter 6 Dehydron as a Marker for Molecular Evolution: Lessons for the Drug Designer.- Chapter 7 Catalytic Role of Dehydrons in Soluble Proteins: Biological Chemistry of Frustrated Interfacial Water.- Chapter 8 Epistructural Selectivity Filters for Molecular Targeted Therapy.- Chapter 9 Epistructural Re-Engineering ofImatinib to Eliminate Adverse Side Effects.- Chapter 10 Epistructural Informatics for the Drug Designer.- Chapter 11 Drug-Target Associations Inducing Protein Folding.-  Chapter 12  Combination Therapies to Edit Out Side Effects and Resistance to Inhibition of Drug Resistance.- Chapter 13 Epistructure-Based Design of Drugs with Controlled Promiscuity.- Chapter 14 Synergizing Engineered Immunotherapy with Molecularly Targeted Cancer Treatment.- Chapter 15 Quantum Mechanical Concepts for Epistructural Drug Design.- Chapter 16 Structure-Based Drug Discovery Without Structure: Working Around the Paradox to Disrupt Protein-Protein Associations.- Chapter 17 Epistructural Drug Design to Treat Cancer Metastasis and the Associated Drug Resistance.

"It does give all of the background information developed by the author who is seeking an understanding at the molecular level of what happens at the protein-water interface. This in itself is a good reason to own the book. It is well written and the diagrams and explanations are clear for both the initiated and newcomer to the field." (Peter J. Dobson, Contemporary Physics, Vol. 58 (4), September, 2017)

“It does give all of the background information developed by the author who is seeking an understanding at the molecular level of what happens at the protein-water interface. This in itself is a good reason to own the book. It is well written and the diagrams and explanations are clear for both the initiated and newcomer to the field.” (Peter J. Dobson, Contemporary Physics, Vol. 58 (4), September, 2017)