Metallomics

Yasumitsu Ogra Professor, Department of Toxicology and Environmental Health, Graduate School of Pharmaceutical Sciences, Chiba University, 1‐8‐1 Inohana, Chuo‐ku, Chiba 260‐8675, Japan Takafumi Hirata Professor, Earth and Planetary Sciences, Graduate School of Science, Kyoto University, Kitashirakawa Oiwake‐cho, Sakyo‐ku, Kyoto 606‐8502, Japan

Part I Overview.- Chapter 1. Metallomics: Integrated Biometal Science.- Part II Analytical techniques and strategies surrounding metallomics.- Chapter 2. Speciation and identification of chalcogen-containing metabolites.- Chapter 3. Visualization of intracellular elements using scanning X-ray fluorescence microscopy.- Chapter 4. Quantitative elemental bioimaging protocol using femtosecond-Laser Ablation-ICP-Mass Spectrometry coupled with glass standard material.- Chapter 5. Single cells analysis by using ICP-MS.- Chapter 6. Synchrotron radiation X-ray analysis of metal accumulating plants.- Chapter 7. 77Se NMR Spectroscopy for Speciation Analysis of Selenium Compounds.- Chapter 8. Protein quantification and quantitative phosphorylation analysis by the determination of hetero atoms (S and P) by means of nanoHPLC-ICPMS.- Chapter 9. Analysis of drug active pharmaceutical ingredients and bio-molecules using triple quadrupole ICP-MS.- Chapter 10. Highly sensitive analysis of proteins and metabolites by metal tagging using LC-ICP-MS.- Part III Application of metallomics in molecular biology, medicine and pharmaceutical sciences.- Chapter 11. Comprehensive element analysis of prokaryotic and eukaryotic cells as well as organelles by ICP-MS.- Chapter 12. Iron isotope signature for red blood cell samples from Japanese female donors of various ages.- Chapter 13. Roles of zinc transporters in cellular transport of cadmium and manganese.- Chapter 14. Link between metal homeostasis and neurodegenerative diseases: crosstalk of metals and amyloidogenic proteins at the synapse.- Chapter 15. New insight into metallomics in cognition.- Chapter 16. Frontier of development for metallodrugs on the basis of metallomic pharmacology and medicinal inorganic chemistry.

“Metallomics: recent analytical techniques and applications seems adequate for Ph.D. students who are trying to approach the topic of metallomics as well as for scientists working in this discipline to update their knowledge of the field. … It provides an overview of fundamental principles, problems and tools for the analysis of biomolecules.” (Maria Montes-Bayón, Analytical and Bioanalytical Chemistry, Vol. 410, 2018)