Maspin

Mary J.C. Hendrix (Autor)

Buch | Hardcover

132 Seiten

2002
CRC Press (Verlag)
978-1-58706-097-7 (ISBN)

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This book represents the first compilation of the major research findings regarding Maspin—a mammary serpin (or serine) protease inhibitor. Maspin was originally discovered through subtractive hybridization and differential display analyses, comparing the differences in gene expression in normal mammary epithelium and invasive carcinoma cells. This work originated in the laboratory of Dr. Ruth Sager, a world-renowned geneticist, at the Dana Farber Cancer Institute and Harvard Medical School. The first introduction of Maspin to the research community occurred as a report in Science (v263:526-529, 1994), and described the unique tumor-suppressing activity of this novel gene in human mammary epithelial cells.

Mary J.C. Hendrix, Department of Anatomy and Cell Biology Holden Comprehensive Cancer Center The University of Iowa Iowa City, Iowa, U.S.A.

Preface 1. Ruth Sager, Geneticist 2. Maspin in the Sager Laboratory 3. Maspin: Functional Insights from a Structural Perspective 4. Maspin and Myoepithelial Cells 5. Maspin and Pericellular Plasminogen Activationin Cell-Matrix Interaction 6. Genetic and Epigenetic Regulation of Maspin Gene Expression in Normal and Tumor Tissue 7. Maspin Suppresses Breast Cancer Cell Invasiveness by Modulating Integrin Expression and Function 8. The Role of Maspin in Tumor Progression and Normal Development 9. The Role of Maspin in Human Placental Development 10. Maspin, a Potential Prognostic Marker for Human Cancers

Erscheint lt. Verlag	1.8.2002
Zusatzinfo	25 Illustrations, black and white
Verlagsort	London
Sprache	englisch
Maße	152 x 229 mm
Gewicht	430 g
Themenwelt	Naturwissenschaften ► Biologie
ISBN-10	1-58706-097-3 / 1587060973
ISBN-13	978-1-58706-097-7 / 9781587060977
Zustand	Neuware