Drosophila Models for Human Diseases (eBook)
X, 308 Seiten
Springer Singapore (Verlag)
978-981-13-0529-0 (ISBN)
Most biological pathways, physical and neurological properties are highly conserved between humans and Drosophila and nearly 75% of human disease-causing genes have a functional homologue in Drosophila. This volume provides recent advances in Drosophila models for various human diseases, with each chapter providing a review of studies involving Drosophila models, as well as detailed protocols commonly used in laboratories. Starting with a review of Drosophila's value as a highly tractable model organism for studying human diseases, subsequent chapters present Drosophila models for specific human diseases.
The book provides a useful resource for all scientists who are starting to use the Drosophila model in their studies, and for researchers working in the pharmaceutical industry and using new screening models to develop new medicines for various diseases.
Masamitsu Yamaguchi received his PhD from Osaka University and is currently a Professor of Applied Biology, Kyoto Institute of Technology. He is a former director of the Advanced Insect Research Promotion Center at Kyoto Institute of Technology.
Most biological pathways, physical and neurological properties are highly conserved between humans and Drosophila and nearly 75% of human disease-causing genes have a functional homologue in Drosophila. This volume provides recent advances in Drosophila models for various human diseases, with each chapter providing a review of studies involving Drosophila models, as well as detailed protocols commonly used in laboratories. Starting with a review of Drosophila's value as a highly tractable model organism for studying human diseases, subsequent chapters present Drosophila models for specific human diseases. The book provides a useful resource for all scientists who are starting to use the Drosophila model in their studies, and for researchers working in the pharmaceutical industry and using new screening models to develop new medicines for various diseases.
Masamitsu Yamaguchi received his PhD from Osaka University and is currently a Professor of Applied Biology, Kyoto Institute of Technology. He is a former director of the Advanced Insect Research Promotion Center at Kyoto Institute of Technology.
Ch1 Drosophila as a model organism
Masamitsu Yamaguchi, Hideki Yoshida, Department of Applied Biology, Kyoto Institute of Technology
Ch2 Adult intestine aging model
Takashi Okumura, Koji Takeda, Takashi Adachi-Yamada, Gakushuin University
Ch3 Alzheimer’s disease model
Leo Tsuda, National Center for Geriatrics and Gerontology (NCGG)
Ch 4 Parkinson’s disease model
Dang Thi Phuong Thao, University of Science, Vietnam National University, Ho Chi Minh City
Chapter 5
Repeat expansion disease model
Morio Ueyama, Yoshitaka Nagai, Osaka University
Ch6 Amyotrophic lateral sclerosis model
Yumiko Azuma, Takahiko Tokuda, Kyoto Prefectural University of Medicine
Ch7 Charcot-Marie-Tooth disease model
Masamitsu Yamaguchi, Hiroshi Takashima, Kyoto Institute of Technology, Kagoshima University
Ch8 Role of long non-coding RNA in neurological diseases
Luca Lo Piccolo, Kyoto Institute of Technology
Ch9 Muscular dystrophy model
Saranyapin Potikanond, Wutigri Nimlamool, Jasprien Noordermeer, Lee Fradkin
Chiang Mai University, Molecular biology department, Leiden University Medical Center (LUMC), Department of Neurobiology, UMass Medical School
Ch10 Cancer model
Tatsushi Igaki, Kyoto University
Ch11 Leukemia model
Lucas Waltzer, Centre de Biologie du Développement, CNRS – Université Paul Sabatier, Toulouse, France
Ch12 Diseases of replication /repair genes
Sue Cotterill, St Georges University of London
Ch13 Drosophila models for studying UPR in insulin-like peptide producing cells and onset of type I diabetes
Yoshihiro H. Inoue, Insect Biomedical Research Center, Kyoto Institute of Technology
Ch14 Metabolomics study on Drosophila models
Phan Nguyen Thuy An, Eiichiro Fukusaki, Graduate School of Engineering, Osaka University
Ch15 Humanized flies for functional analysis of the human genome and cross-species comparison
Toshiyuki Takano-Shimizu, Department of Drosophila Genomics and Genetic Resources, Kyoto Institute of Technology
Ch16 Designs for Flies
Frank Kolkman, Julia Cassim, Royal College of Arts, Kyoto Institute of Technology
| Erscheint lt. Verlag | 27.6.2018 |
|---|---|
| Reihe/Serie | Advances in Experimental Medicine and Biology | Advances in Experimental Medicine and Biology |
| Zusatzinfo | X, 308 p. 79 illus., 64 illus. in color. |
| Verlagsort | Singapore |
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Innere Medizin |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie | |
| Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie | |
| Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik | |
| Naturwissenschaften ► Biologie ► Humanbiologie | |
| Naturwissenschaften ► Biologie ► Zellbiologie | |
| Naturwissenschaften ► Biologie ► Zoologie | |
| Schlagworte | Animal model • Drug screen • Gene function • Metabolic disease • Metabolomics • Neurology |
| ISBN-10 | 981-13-0529-3 / 9811305293 |
| ISBN-13 | 978-981-13-0529-0 / 9789811305290 |
| Haben Sie eine Frage zum Produkt? |
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