Imaging in Movement Disorders: Imaging in Atypical Parkinsonism and Familial Movement Disorders

Professor Marios Politis (MD MSc DIC PhD FRCP FEAN) is a Professor of Neurology, Consultant Neurologist, the Director of Neurodegeneration Imaging Group and the Director of Mireille Gillings Neuroimaging Centre at the University of Exeter. His research involves the use of Positron Emission Tomography (PET) and Single Photon Emission Tomography (SPECT) molecular imaging, structural and functional Magnetic Resonance Imaging (MRI), CSF and blood molecular markers, digital markers and clinical observation as methods of investigating aetiology, pathophysiology, and effects and complications of novel therapies in Neurodegenerative disorders. Professor Marios Politis has receive a high number of awards for clinical, research, and clinical research excellence including a research achievement award by the MRC (2010), the Movement Disorder Society Award for Outstanding and Innovative Clinical Research (2012), the IMPETus award for innovative and outstanding PET molecular imaging research (2013, 2014, 2015, 2016) and the PET Investigator Award from the Society of Nuclear Medicine and Molecular Imaging (2015). In 2016, he was elected Fellow of the European Academy of Neurology for outstanding contribution in neurodegenerative research. In 2017, he received the Jon Stolk Award in Movement Disorders from the American Academy of Neurology and was elected Fellow of Royal College of Physicians. Professor Marios Politis has significant industry experience by serving as a clinical investigator, consultant and principal investigator in several collaborations with industrial partners and pharma including a number of clinical trials. He has trained over 120 clinical and non-clinical fellows, research associates and research assistants, and undergraduate and postgraduate students at NIG. He has raised a record amount of over £60 million for cutting-edge research in neurodegenerative conditions such as Parkinson’s disease, Alzheimer’s disease and other neurodegenerative disorders; and is actively collaborating with a high number of philanthropic, government, non-commercial and commercial industrial partners. Professor Marios Politis has published over 150 high impact papers and has been running a specialist Neurology and Movement Disorder clinical service for over 15 years with previous appointments at UCLH, Hammersmith and Charring Cross Hospitals, and King’s College Hospital.

Section 1: Imaging Applications in Atypical Parkinsonism 1. PET Molecular Imaging in Atypical Parkinsonism Zheyu Xu, Javier Arbizu and Nicola Pavese 2. SPECT Molecular Imaging in Atypical Parkinsonism Joachim Brumberg and Ioannis U. Isaias 3. Structural Imaging in Atypical Parkinsonism Beatrice Heim, Florian Krismer and Klaus Seppi 4. Functional MRI in Atypical Parkinsonisms Federica Agosta, Elisabetta Sarasso and Massimo Filippi

Section 2: Imaging Applications in Familial Movement Disorders 5. PET Molecular Imaging in Familial Parkinson's Disease Michele Matarazzo, Daryl Wile, Melissa Mackenzie and A. Jon Stoessl 6. SPECT Molecular Imaging in Familial Parkinson's Disease Andrea Varrone and Maria Teresa Pellecchia 7. Structural and Functional MRI in Familial Parkinson’s Disease Avner Thaler 8. Molecular Imaging in Huntington's Disease Heather Wilson and Marios Politis 9. Structural Magnetic Resonance Imaging in Huntington’s Disease Heather Wilson, George Dervenoulas and Marios Politis 10. Functional Magnetic Resonance Imaging in Huntington’s Disease Sarah Gregory and Rachael I. Scahill