Personalized Psychiatry

Prof. Bernhard Baune (PhD, MD, MPH, FRANZCP) is the Director of the University Hospital Department of Psychiatry and Psychotherapy, University of Münster, Germany. He also leads the newly established Laboratory Division of Molecular Neurobiology of Mental Health at the University. Prof. Baune has been the Cato Chair and Head of Department of Psychiatry at the University of Melbourne, Australia prior to being awarded the Director position at the University of Münster. Prof. Baune is a Fellow of the Royal Australian and New Zealand College of Psychiatrist (FRANZCP), he is a Professorial Fellow of the Department of Psychiatry, University of Melbourne and also at the Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Australia. Prof. Baune is known for his extensive research program into depression and cognitive dysfunction, personalised psychiatry, molecular psychiatry, prediction and biomarker research and treatment response research as well as for key research achievements in the field of immune-neurobiology of psychiatric disorders. Prof. Baune’s translational work at the University of Münster is designed to make real-world differences to the lives of people with mental illness by integrating neurobiological and clinical information, by personalising treatments and by targeting the mechanisms of functional recovery. Other related work include the leadership of an international consortium on the genomics of severe depression and response to ECT in affective disorders (GenECT-ic), leading an international study on the genomics of cognitive function in depression and directing the ECNP network on trans- diagnostic pharmacogenomics and transcriptomics in psychiatric disorders. His research is nationally and internationally recognised and he has published more than 500 peer-reviewed articles, reviews and book chapters, and he edited several text books in Psychiatry, and most recently the books “Personalised Psychiatry” (Elsevier), “Inflammation and Immunity of Depression” (Elsevier) and “Cognitive Dimensions of Major Depressive Disorder” (Oxford University Press).

Preface
Bernhard Theodor Baune
1. What is personalized psychiatry and why is it necessary?
Bernhard Theodor Baune
2. The modeling of trajectories in psychotic illness
Scott R. Clark, Klaus Oliver Schubert, and Bernhard T. Baune
3. Mood trajectories as a basis for personalized psychiatry in young people
Klaus Oliver Schubert, Scott R. Clark, Linh K. Van, Jane L. Collinson, and Bernhard T. Baune
4. Transdiagnostic early intervention, prevention, and prediction in psychiatry
Cristina Mei, Barnaby Nelson, Jessica Hartmann, Rachael Spooner, and Patrick D. McGorry
5. Early intervention, prevention, and prediction in mood disorders: Tracking multidimensional outcomes in young people presenting for mental health care
Elizabeth M. Scott, Joanne S. Carpenter, Frank Iorfino, Shane P.M. Cross, Daniel F. Hermens, Django White, Rico S.Z. Lee, Sharon L. Naismith, Adam J. Guastella, Nicholas Glozier, F. Markus Leweke, Dagmar Koethe, Jim Lagopoulos, Jan Scott, Blake A. Hamilton, Jacob J. Crouse, Ashleigh M. Tickell, Alissa Nichles, Natalya Zmicerevska, Lillian J. Gehue, Manreena Kaur, Kate M. Chitty, and Ian B. Hickie
6. Consumer participation in personalized psychiatry
Harris A. Eyre, Elisabeth R.B. Becker, Marissa S. Blumenthal, Ajeet B. Singh, Cyrus Raji, Arshya Vahabzadeh, Zoe Wainer, and Chad Bousman
7. Experimental validation of psychopathology in personalized psychiatry
Alfons O. Hamm
8. Deep brain stimulation for major depression: A prototype of a personalized treatment in psychiatry
Thomas E. Schlaepfer and Bettina H. Bewernick
9. The Psychiatric Genomics Consortium: History, development, and the future
Hunna J. Watson, Zeynep Yilmaz and Patrick F. Sullivan
10. Statistical genetic concepts in psychiatric genomics
Darina Czamara and Divya Mehta
11. Opportunities and challenges of machine learning approaches for biomarker signature identification in psychiatry
Han Cao and Emanuel Schwarz
12. Personalized psychiatry with human iPSCs and neuronal reprogramming
Cedric Bardy, Zarina Greenberg, Seth W. Perry and Julio Licinio
13. Genetics of alcohol use disorder
Jill L. Sorcher and Falk W. Lohoff
14. Genomics of autism spectrum disorders
Margarita Raygada, Paul Grant and Owen M. Rennert
15. Genomics of schizophrenia
A. Corvin, C. Ormond and A.M. Cole
16. Genomics of major depressive disorder
Douglas F. Levinson
17. Personalized mental health: Artificial intelligence technologies for treatment response prediction in anxiety disorders
Ulrike Lueken and Tim Hahn
18. The genetic architecture of bipolar disorder: Entering the road of discoveries
Olav B. Smeland, Andreas J. Forstner, Alexander Charney, Eli A. Stahl and Ole A. Andreassen
19. Genomics of borderline personality disorder
Fabian Streit, Lucı´a Colodro-Conde, Alisha S.M. Hall and Stephanie H. Witt
20. Genetics of obsessive-compulsive disorder and Tourette disorder
Christie L. Burton, Csaba Barta, Danielle Cath, Daniel Geller, Odile A. van den Heuvel, Yin Yao, (Obsessive Compulsive Disorder and Tourette Syndrome Working Group of the Psychiatric Genomics Consortium), Valsamma Eapen, Edna Grünblatt and Gwyneth Zai
21. Genetics and pharmacogenetics of attention deficit hyperactivity disorder in childhood and adulthood
Cristian Bonvicini, Carlo Maj and Catia Scassellati
22. Genomics of Alzheimer’s disease
Margot P. van de Weijer, Iris E. Jansen, Anouk H.A. Verboven, Ole A. Andreassen and Danielle Posthuma
23. Current progress and future direction in the genetics of PTSD: Focus on the development and contributions of the PGC-PTSD working group
Angela G. Junglen, Christina Sheerin, Douglas L. Delahanty, Michael A. Hauser, Adriana Lori, Rajendra A. Morey, Caroline M. Nievergelt, Nicole R. Nugent, Jonathan Sebat, Alicia K. Smith, Jennifer A. Sumner, Monica Uddin and Ananda B. Amstadter
24. Genomic contributions to anxiety disorders
Shareefa Dalvie, Nastassja Koen and Dan J. Stein
25. Proteomics for diagnostic and therapeutic blood biomarker discovery in schizophrenia and other psychotic disorders
David R. Cotter, Sophie Sabherwal and Klaus Oliver Schubert
26. Molecular biomarkers in depression: Toward personalized psychiatric treatment
Anand Gururajan, John F Cryan and Timothy G Dinan
27. Neuroimaging biomarkers of late-life major depressive disorder pathophysiology, pathogenesis, and treatment response
Helmet T. Karim, Charles F. Reynolds, III and Stephen F. Smagula
28. Copy number variants in psychiatric disorders
Franziska Degenhardt
29. Gene-environment interaction in psychiatry
Hans Jörgen Grabe and Sandra Van der Auwera
30. Epigenetics: A new approach to understanding mechanisms in depression and to predict antidepressant treatment response
Helge Frieling, Stefan Bleich and Alexandra Neyazi
31. Gene coexpression network and machine learning in personalized psychiatry
Liliana G. Ciobanu, Micah Cearns and Bernhard T. Baune
32. Pharmacogenomics of bipolar disorder
Claudia Pisanu, Alessio Squassina, Martin Alda and Giovanni Severino
33. Pharmacogenomics of treatment response in major depressive disorder
Joanna M. Biernacka, Ahmed T. Ahmed, Balwinder Singh and Mark A. Frye
34. Genomic treatment response prediction in schizophrenia
Sophie E. Legge, Antonio F. Pardiñas and James T.R. Walters　
35. Personalized treatment in bipolar disorder
Estela Salagre, Eduard Vieta and Iria Grande
36. Genetic testing in psychiatry: State of the evidence
Chad A. Bousman, Lisa C. Brown, Ajeet B. Singh, Harris A. Eyre and Daniel J. Müller
37. Opportunities and challenges of implementation models of pharmacogenomics in clinical practice
Jonathan C.W. Liu, Ilona Gorbovskaya, Chad Bousman, Lisa C. Brown and Daniel J. Müller
38. Metabolomics in psychiatry
Renee-Marie Ragguett and Roger S. McIntyre
39. Real-time fMRI brain-computer interface: A tool for personalized psychiatry?
David E.J. Linden
40. How functional neuroimaging can be used for prediction and evaluation in psychiatry
Beata R. Godlewska and Catherine J. Harmer
41. Neuroimaging, genetics, and personalized psychiatry: Developments and opportunities from the ENIGMA consortium
Lianne Schmaal, Christopher R.K. Ching, Agnes B. McMahon, Neda Jahanshad and Paul M. Thompson
42. Applying a neural circuit taxonomy in depression and anxiety for personalized psychiatry
Leanne M. Williams and Andrea N. Goldstein-Piekarski
43. Multimodal modeling for personalized psychiatry
Scott R. Clark, Micah Cearns, Klaus Oliver Schubert and Bernhard T. Baune
44. Standardized biomarker and biobanking requirements for personalized psychiatry
Catherine Toben, Victoria K. Arnet, Anita Lo, Pamela H. Saunders and Bernhard T. Baune
45. Ethical, policy, and research considerations for personalized psychiatry
Ryan Abbott, Donald D. Chang and Harris A. Eyre
46. The future of personalized psychiatry
Bernhard T. Baune