Translational Neuroscience

Mark H. Tuszynski, MD, PhD, is a professor of neurosciences and founding director of the Translational Neuroscience Institute at the University of California – San Diego, and a neurologist at the Veterans Administration Medical Center in La Jolla, California. He received his undergraduate and MD degrees from the University of Minnesota in Minneapolis, completed neurology residency at Cornell University Medical Center / The New York Hospital, and subsequently received a PhD in neuroscience from the University of California – San Diego.  Dr. Tuszynski studies basic and translational aspects of neurodegenerative disorders and neurotrauma, and the biological basis of learning and memory.

Introduction.- Gene Therapy of CNS Disorders using Recombinant AAV vectors.- NGF and BDNF Gene Therapy for Alzheimer’s Disease.- GDNF and AADC Gene Therapy for Parkinson’s Disease.- GAD Gene Therapy for Parkinson’s Disease.- Anti-sense Oligonucleotides for Amyotrophic Lateral Sclerosis.- Gene therapy for Inborn Errors of Metabolism: Batten Disease.- Gene Therapy for Spinal Cord Injury.- Gene Therapy for Epilepsy.- Translating Gene Therapy for Pain from Animal Studies to the Clinic.- Stem Cells for Parkinson’s Disease.- Could Stem Cells be used to treat or model Alzheimer’s Disease?.- Stem cells for Amyotrophic Lateral Sclerosis.- Stem cells for Multiple Sclerosis.- Cell Therapy for Pediatric Disorders of Glia.- Neural Stem Cells for Spinal Cord Injury.- Marrow-derived Mesenchymal Stromal Cells in the Treatment of Stroke.- Glioma Stem Cells.- Discovery of Potent Gamma Secretase Modulators for the Treatment of Alzheimer’s Disease.- Blocking the Nogo-A signalling pathway to promote regeneration and plasticity after spinal cord injury and stroke.- Intrinsic neuronal mechanisms in axon regeneration after spinal cord injury.- Voltage-gated ion channels as molecular targets for pain.- Rehabilitation-dependent neural plasticity after Spinal Cord Injury.- Neural Prostheses for Neurotrauma.- Why is Functional Electrical Stimulation Therapy Capable of Restoring Motor Function Following Severe Injury to the Central Nervous System? .- Deep Brain Stimulation for Neuropsychiatric Disorders.- Novel Interventions for Stroke: Nervous System Cooling.- Rehabilitation Strategies For Restorative Approaches After Stroke and Neurotrauma.- Bridging the Chasm between Scientific Discovery and a Pivotal Clinical Trial for a CNS Disorder: A Checklist.- Conclusion.