Regenerative Therapies for Liver Disease

Stephen Strom, Ph.D. is the Söderberg Professor, in the Cell Transplantation and Regenerative Medicine, Department of Laboratory Medicine, Pathology at the Karolinska Institutet in Stockholm, Sweden. He is the author or co-author of over 200 published peer reviewed articles and dozens of invited book chapters.

Overview of Human Hepatocyte Transplantation. Encapsulated hepatocyte therapy of acute liver failure. Bioartificial liver support for acute liver failure. Recellularized-bioengineered liver tissues for transplantation. Cellular therapies of acute liver failure and fibrosis. Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy. Treatment of end stage cirrhosis by enforced expression of Hepatocyte Nuclear Factor 4. The role of immune cells (or macrophages) in liver disease and regeneration. In vivo reprogramming of myofibroblasts with AAV vectors as a therapeutic strategy for liver fibrosis. Direct reprogramming of hepatic myofibroblasts into hepatocytes, in vivo, attenuates liver fibrosis. In utero stem cell transplantation and gene therapy: rationale, history, and recent advances toward clinical application. The emerging roles of microvesicles in liver disease and therapy. Amnion epithelial stem cell therapy of metabolic liver disease. Gene therapy for rare metabolic liver diseases. Gene editing technology for the therapy of rare liver diseases.