Progranulin

A Brief Overview of Progranulin in Health and Disease.- Chromatographic Methods for the Purification of Granulin Peptides.- Methods for Expression and Purification of Biologically Active Recombinant Progranulin.- Large-Scale Generation of Recombinant Granulin Peptides in E. coli.- Nuclear Magnetic Resonance Spectroscopy in Analysis of Granulin Three-Dimensional Structure and Cysteine Bridging.- Data Mining: Applying the AD&FTD Mutation Database to Progranulin.- Measurement of Circulating Progranulin (PGRN/GP88/GEP) by Enzyme-Linked Immunosorbent Assay and Application in Human Diseases.- Immunohistochemical Detection of Progranulin (PGRN/GP88/GEP) in Tumor Tissues as a Cancer Prognostic Biomarker.- Analysis of Progranulin-Mediated Akt and MAPK Activation.- Mouse Monoclonal Antibodies Against Progranulin (PGRN/GEP) as Therapeutics in Preclinical Cancer Models.- Methods to Analyze the Role of Progranulin (PGRN/GEP) on Cancer Stem Cell Features.- Methods to Study the Role of Progranulin in the Tumor Microenvironment.- Methods to Investigate the Molecular Basis of Progranulin Action on Neurons In Vivo using Caenorhabditis elegans.- The Use of Caenorhabditis elegans to Study Progranulin in the Regulation of Programmed Cell Death and Stress Response.- Application of Zebrafish and Knockdown Technology to Define Progranulin Neuronal Function.- Methods to Investigate the Molecular Basis of Progranulin Actions on Brain and Behavior In Vivo Using Knockout Mice.- Methods to Investigate the Protection Againts Neurodegenerative Disorders Provided by Progranulin Gene Transfer in the Brain.- The Interaction between Progranulin with Sortilin and the Lysosome.- Methods to Study the Role of Progranulin in Preimplanatation Mouse Embryo Development.- Establishment of a Modified Collagen-Induced Arthritis Mouse Model to Investigate the Anti-Inflammatory Activity of Progranulinin Inflammatory Arthritis.- Methods for Studying the Function of Progranulin in Atherosclerosis using Both Knockout Mice Models and In Vitro Studies.- Methods to Investigate the Roles of Prgranulin in Angiogenesis Using In Vitro Strategies and Transgenic Mouse Models.