Implementing Precision Medicine in Best Practices of Chronic Airway Diseases

Ioana Agache is Professor in Allergy and Clinical Immunology at Transylvania University, Brasov, Romania and President of the European Academy of Allergy and Clinical Immunology (EAACI) 2017-2019. Her research in the field of Asthma and Allergy and Clinical Immunology focused on several key areas, ranging from asthma phenotypes and endotypes and immune modulation and immune tolerance to the concept of integrated management of allergic diseases, with a special focus on the primary care system and the community pharmacists. She is member of the Steering Committee and co-author of several international and European Guidelines, such as ARIA (Allergic Rhinits and its impact on Asthma), EAACI Allergen Immunotherapy Guidelines and EAACI Food Allergy and Anaphylaxis Guidelines. She is Editor of the Global Atlas of Asthma (2013), Global Atlas of Allergy (2014), Global Atlas of Allergic Rhinitis and Chronic Rhinosinusitis (2015), Associate Editor of Clinical and Translational Allergy and a member of the Editorial Board for Journal of Allergy and Clinical Immunology and Allerhy. Ioana Agache graduated with a medical degree from “Carol Davila” University, Bucharest and absolved Magna Cum Laude her PhD in Internal Medicine. Since August 2004 Dr. Peter Hellings has been working at the Dept. of Otorhinolaryngoloy of the University Hospitals Leuven and was nominated docent and head docent at the KU Leuven in 2004 and 2008 respectively. He has been nominated full professor (hoogleraar) at the KU Leuven in Oct. 2012. Since 2014, he is also nominated full professor (hoogleraar) at the Academic Medical Center in Amsterdam, and nominated guest professor at the University of Ghent in 2015. He has been the organizing president of the annual meeting of the European Academy of Facial Plastic Surgery in Bruges in 2011, under the High Patronage ofH.R.H.ueen Mathilde of Belgium, and of the bi-annual European scientific SERIN meeting in Leuven in 2013, under the High Patronage of H.R.H. Princess Astrid of Belgium. He became member of the Royal Academy of Medicine of Belgium in 2012, and current secretary of the Commission International Relations. After being chair of the ENT section, he is the Secretary-General of the European Academy of Allergy

Part I The Concept of Precision Medicine and Precision Health 1. The Audacious Goal of Precision Medicine 2. Critical Entry Points—Genetics and Epigenetics 3. Critical Entry Points—Microbiome 4. Factors Modulating the Disease Endotype 5. Revised Disease Nomenclature Including Disease Endotypes

Part II Shortcomings of Current Care Pathways for Chronic Airways Diseases 6. The Global Burden of Chronic Airway Diseases 7. Unmet Needs in Chronic Upper Respiratory

Part III Personalized Care: Endotype-driven Treatment 8. Endotype-Driven Approach for Asthma 9. Endotype-Driven Approach for Chronic Rhinosinusitis 10. Endotype-Driven Approach in Rhinitis 11. Prevention of Allergies 12. Prevention of Asthma 13. Prevention of Chronic Rhinosinusitis 14. Current and Future Biomarkers for Allergy and Asthma 15. Validation and Qualification of Biomarkers and Their Translation Into Pathway-Specific Diagnostic Tests 16. Critical Issues for the Endotype/Biomarkers Approach 17. Key Points for Moving the Endotypes Field Forward

Part IV Health Information Technology and PM 18. Telemedicine and Mobile Health Technology in the Diagnosis, Monitoring and Treatment of Respiratory Allergies 19. Real-Time Clinical Decision Support at the Point of Care 20. Patient-Friendly HIT Tools and the Advent of Crowdsourcing Clinical Trials

Part V Participation of the Patient 21. The Patient-Centered Decision System as per the 4Ps of PRECISION MEDICINE 22. Interpersonal Dimensions of Personalized Medicine for Chronic Obstructive Pulmonary Disease

Part VI Bringing Precision Medicine to the Clinic 23. Big Data Translation Into Clinical Decision Algorithms 24. European Union Funding of Research on Airway Diseases 25. Provision of Care - Implementation of the Finnish Allergy Programme 2008-2018 26. Improving Understanding and Common Usage of Disease Phenotypes, Endotypes, Biomarkers and Precision Therapies at the Point of Care 27. Full Patient Monitoring Using Digital Health Technology 28. Global Multidisciplinary Networks 29. EUFOREA Approach to Precision Medicine in Respiratory Diseases