Interleukin-2 and Killer Cells in Cancer

Lotzova, Eva

1. Cellular Immunotherapy of Cancer: Preclinical and Clinical Testing Utilizing Interleukin-2 2. Long-Term Culture of IL-2-Generated Killer Cells with Antitumor Activity 3. Function of Interleukin-2 Activated NK Cells in Leukaemia Resistance and Treatment 4. Utilizing Lymphokine-Activated Killer Cells for Bone Marrow Purging 5. Cell-Mediated Cytotoxicity Against Fresh Solid Tumor Cells 6. Regulation by Soluble Mediators 7. Down-Regulation of Human Bone Marrow Cells and Their Progenitors by IL-2 Activated Lymphocytes 8. IL-2-Induced Cytotoxic Cells From Human Thymocytes. Regulation of NK Cytotoxicity In Vivo in Patients Receiving IL-2 9. Synergism Between Cyclophosphamide and Interleukin-2 10. Human TIL and Their Characterization 11. Growth Kinetics, Function and Characterization of Tumor-Infiltrating Lymphocytes from Human Ovarian Cancers 12. Cancer Treatment Using IL-2-Activated Killer Cells and/or IL-2 in Combination with Chemotherapeutic Drugs: Animal Studies 13. Development of Adoptive Immunotherapy with In Vitro Sensitized T Lymphocytes from Mice Bearing Progressively Growing Tumors 14. Adoptive Transfer of T Cells for Therapy of Disseminated Leukemia: Antigen Specificity and Function of Tumor-Reactive T Cells 15. LAK Cells and Autologous Bone Marrow Transplantation: Toward a Cure for Leukaemia 16. Tumor Inhibitory Effects of Regional Interleukin-2 Administration and the Role of Lymphokine-Activated Killer Cells 17. Tissue Distribution and Localization of IL-2 Activated Killer Cells After Adoptive Transfer In Vivo 18. In Vivo Tissue Distribution of Interleukin-2 Activated Cells 19. Role of rIL-2 in Host Resistance Against Cryptococcal Infection 20. Role of IL-2 in Growth and Differentiation of Cytotoxic Cells 21. The Interleukin-2 Receptor Complex and Its Role in the Induction of Nonspecific Cytotoxicity 22. Regulation of Phosphorylation and Gene Expression in Cytotoxic Lymphocytes by Interleukin-2 23. Role of the Interleukin-2 Receptor in the Growth and Regulation of LAK Activity 24. Surface Structures Involved in Tumor Cell