Hepatitis B Virus and Liver Disease -

Hepatitis B Virus and Liver Disease (eBook)

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2018 | 1st ed. 2018
XVII, 360 Seiten
Springer Singapore (Verlag)
978-981-10-4843-2 (ISBN)
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This book provides a comprehensive, state-of-the art review of HBV infection and liver disease. It discusses new data on basic and translational medicine, including the viral life cycle, the immunopathogenesis of virus-induced chronic hepatitis, viral and host genetic factors affecting disease progression, and the mechanism of virus-induced hepatocarcinogenesis, as well as their potential applications in daily clinical practice. The clinical aspects of chronic HBV infection are examined in chapters on the global epidemiology, efficacy of HBV vaccination, natural history, co-infections with HCV, HDV or HIV, and management of special populations including children, pregnant women and patients undergoing immunosuppressive therapy. Further, it describes the advances and perspectives in the development of novel antiviral treatments as possible cures for HBV infection. The book is a valuable resource for medical students, physicians, and researchers who are interested in managem

ent of patients with chronic HBV infection and investigation of HBV infection.



Editor Jia-Horng Kao is a Professor at the Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan. Professor Ding-Shinn Chen is a Professor at the Genomics Research Center, and the Academician of Academic Sinica, Taipei, Taiwan.


This book provides a comprehensive, state-of-the art review of HBV infection and liver disease. It discusses new data on basic and translational medicine, including the viral life cycle, the immunopathogenesis of virus-induced chronic hepatitis, viral and host genetic factors affecting disease progression, and the mechanism of virus-induced hepatocarcinogenesis, as well as their potential applications in daily clinical practice. The clinical aspects of chronic HBV infection are examined in chapters on the global epidemiology, efficacy of HBV vaccination, natural history, co-infections with HCV, HDV or HIV, and management of special populations including children, pregnant women and patients undergoing immunosuppressive therapy. Further, it describes the advances and perspectives in the development of novel antiviral treatments as possible cures for HBV infection. The book is a valuable resource for medical students, physicians, and researchers who are interested in management of patients with chronic HBV infection and investigation of HBV infection.

Editor Jia-Horng Kao is a Professor at the Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan. Professor Ding-Shinn Chen is a Professor at the Genomics Research Center, and the Academician of Academic Sinica, Taipei, Taiwan.

Life cycle and molecular virology.- Unmet needs in basic research: in vitro and in vivo models.- Immunopathogenesis.- Epidemiology and natural history.- Hepatitis B vaccination.- Viral factors and disease progression.- Host genetic factors and disease progression.- Molecular carcinogenesis of HCC.- Interferon therapy and long-term outcomes.- Nucleotide therapy and long-term outcomes.- Combination therapy.- Treatment of patients with HCV, HDV or HIV co-infection.- Management of children and pregnant women.- Management of patients with immunosuppressive therapy.- Towards an HBV cure: discovery of novel agents.- Others: occult HBV infection.

Erscheint lt. Verlag 12.1.2018
Zusatzinfo XVII, 360 p. 40 illus., 29 illus. in color.
Verlagsort Singapore
Sprache englisch
Themenwelt Medizin / Pharmazie Allgemeines / Lexika
Medizinische Fachgebiete Innere Medizin Hepatologie
Medizin / Pharmazie Medizinische Fachgebiete Mikrobiologie / Infektologie / Reisemedizin
Studium Querschnittsbereiche Infektiologie / Immunologie
Naturwissenschaften Biologie
Schlagworte Chronic Hepatitis • HBV • Hepatitis B Virus • hepatocellular carcinoma • hepatology • Immunopathogenesis • Immunosuppressive therapy • Infectious Diseases • liver cirrhosis
ISBN-10 981-10-4843-6 / 9811048436
ISBN-13 978-981-10-4843-2 / 9789811048432
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