Harper's Illustrated Biochemistry Thirty-First Edition

Robert K. Murray, MD, PhD Professor (Emeritus) of Biochemistry University of Toronto Toronto, Ontario Daryl K. Granner, MD Joe C. Davis Professor of Biomedical Science Director, Vanderbilt Diabetes Center Professor of Molecular Physiology and Biophysics and of Medicine Vanderbilt University Nashville, Tennessee Peter A. Mayes, PhD, DSc Emeritus Professor of Veterinary Biochemistry Royal Veterinary College University of London London Victor W. Rodwell, PhD Professor of Biochemistry Purdue University West Lafayette, Indiana

Preface
SECTION I Structures & Functions of Proteins & Enzymes
1 Biochemistry & Medicine
2 Water & pH
3 Amino Acids & Peptides
4 Proteins: Determination of Primary Structure
5 Proteins: Higher Orders of Structure
SECTION II Enzymes: Kinetics, Mechanism, Regulation, & Role of Transition Metals
6 Proteins: Myoglobin & Hemoglobin
7 Enzymes: Mechanism of Action
8 Enzymes: Kinetics
9 Enzymes: Regulation of Activities
10 The Biochemical Roles of Transition Metals
SECTION III Bioenergetics
11 Bioenergetics: The Role of ATP
12 Biologic Oxidation
13 The Respiratory Chain & Oxidative Phosphorylation
SECTION IV Metabolism of Carbohydrates
14 Overview of Metabolism & the Provision of Metabolic Fuels
15 Carbohydrates of Physiological Significance
16 The Citric Acid Cycle: The Central Pathway of Carbohydrate, Lipid, & Amino Acid Metabolism
17 Glycolysis & the Oxidation of Pyruvate
18 Metabolism of Glycogen
19 Gluconeogenesis & the Control of Blood Glucose
20 The Pentose Phosphate Pathway & Other Pathways of Hexose Metabolism
SECTION V Metabolism of Lipids
21 Lipids of Physiologic Significance
22 Oxidation of Fatty Acids: Ketogenesis
23 Biosynthesis of Fatty Acids & Eicosanoids
24 Metabolism of Acylglycerols & Sphingolipids
25 Lipid Transport & Storage
26 Cholesterol Synthesis, Transport, & Excretion
SECTION VI Metabolism of Proteins & Amino Acids
27 Biosynthesis of the Nutritionally Nonessential Amino Acids
28 Catabolism of Proteins & of Amino Acid Nitrogen
29 Catabolism of the Carbon Skeletons of Amino Acids
30 Conversion of Amino Acids to Specialized Products
31 Porphyrins & Bile Pigments
SECTION VII Structure, Function, & Replication of Informational Macromolecules
32 Nucleotides
33 Metabolism of Purine & Pyrimidine Nucleotides
34 Nucleic Acid Structure & Function
35 DNA Organization, Replication, & Repair
36 RNA Synthesis, Processing, & Modification
37 Protein Synthesis & the Genetic Code
38 Regulation of Gene Expression
39 Molecular Genetics, Recombinant DNA, & Genomic Technology
SECTION VIII Biochemistry of Extracellular & Intracellular Communication
40 Membranes: Structure & Function
41 The Diversity of the Endocrine System
42 Hormone Action & Signal Transduction
SECTION IX Special Topics (A)
43 Nutrition, Digestion, & Absorption
44 Micronutrients: Vitamins & Minerals
45 Free Radicals & Antioxidant Nutrients
46 Glycoproteins
47 Metabolism of Xenobiotics
48 Clinical Biochemistry
SECTION X Special Topics (B)
49 Intracellular Traffic & Sorting of Proteins
50 The Extracellular Matrix
51 Muscle & the Cytoskeleton
52 Plasma Proteins & Immunoglobulins
53 Red Blood Cells
54 White Blood Cells
SECTION XI Special Topics (C)
55 Hemostasis & Thrombosis
56 Cancer: An Overview
57 The Biochemistry of Aging
58 Biochemical Case Histories
The Answer Bank
Index