Emerging Drugs and Targets for Parkinson''s Disease (eBook)

Overview on Parkinson disease. Rational for pharmacological intervention; Dopaminergic pathway and L-Dopa treatments. Future challenges; COMT Inhibitors: present problems and relevance of the new ones; MAO inhibitors for PD (Safinamide); Dopamine agonist: present and future (Pardoprunox); Therapies for dopaminergic-induced dyskinesias in Parkinson disease. (Fipamizole); Beyond the dopamine receptor: regulation of protein phosphatases; Molecular chaperones as rational drug targets for Parkinson's disease therapeutics; Alpha-synuclein assembly as a therapeutic target of PD; Alpha-synuclein (alpha-syn) phosphorylating polo-like kinase 2 (PLK2) as target for PD; Hsp70 molecular chaperones and Parkinson's disease; Glutamate receptors as therapeutic targets for Parkinson's disease; Targeting adenosine A2A receptors in Parkinson's disease; Leucine-rich repeat kinase-2 as target for Parkinson's disease; Phosphodiesterase inhibitors for PD treatment; P2X7 purinergic receptor: role in neurological disorders; Therapeutic role of 5-HT1A receptors in the treatment of schizophrenia and Parkinson's disease; D3 dopamine receptor agonists: neuroprotection in Parkinson's disease; Antioxidants and PD; Tryptophan metabolism in Parkinson's disease; Grafted neural stem cell-derived dopaminergic neurons for PD Therapy; Gene therapy for Parkinson's disease; Carotid body autotransplantation in Parkinson disease;Neurotrophic factor therapy for Parkinson's disease