Zic family

Jun Aruga is a professor of pharmacology at Nagasaki University Institute of Biomedical Sciences, and a former head of the Laboratory for Behavioral and Developmental Disorder at RIKEN Brain Science Institute. He has been researching the biological significance of ZIC family genes since their discovery in 1991.

Part1: Zic family in animal evolution and development. Comparative genome analysis of Zic genes.- Drosophila Zic genes.- Nematode Zic genes.- Planarian Zic genes.- Ascidian  (Halocynthia) Zic genes.- Ascidian  (Ciona) Zic genes.- Amphibian Zic genes.- Teleost fish  (Oryzias) Zic genes.- Teleost fish (Danio) Zic genes.- Overview of rodent Zic genes.- Rodent Zic genes in neural network wiring.- Rodent Zic genes in meninx and vasculature development.- Part2　ZIC family in Medicine: ZIC family as the causative genes for developmental disorders. ZIC1 in Dandy-Walker malformation.- ZIC2 in holoprosencephaly  Maximilian.- Ch.16 ZIC3 in heterotaxy.- Part3　ZIC family in Medicine: ZIC family in stem cell biology. Role of Zic family in transcriptional regulation and chromatin remodeling.- Deregulation of ZIC family in oncogenesis.- ZIC family and stemness.-  ZIC2 in cancer stem cell.