Energetics of Secretion Responses

Jan-Willem N. Akkerman, Ph.D. is the Director of the Laboratory of Haematology in the Department of Haematology at the University of Utrecht, the Netherlands. He received his Ph.D. Degree in 1975 on a these entitled ‘Human Platelet Glycolysis’ and was a visiting staff member at the Thrombosis Research Center at Temple University Philadelphia, Pa. in 1978. His research efforts are in the field of thrombosis and atherosclerosis, with special emphasis on the role of blood platelet and the mechanisms that make these cells response to platelet activating agents. His current research interests are the energetics of platelet functions, mechanisms for signal transduction and abnormal platelet behaviour in patients with bleeding disorders or hyperaggregability.

1. Introduction 2. Cellular Energetics 2. PreStimulation Events: Biosynthesis and Storage of Secretory Proteins 3. Transport and Storage of Biogenic Amines in Adrenal Chromaffin Granules 4.Maintenance of Responsivity 5.Energy-Dependent Steps in Signal Processing: Ligand-Induced Surface Receptor Movement and Transmembrane Interactions 6. The Role of Membrane Potentials and of Intracellular pH in Secretory Cell Stimulation 7. Phosphoinositide Metabolism. Index.