GAPDH: Biological Properties and Diversity - Norbert W. Seidler

GAPDH: Biological Properties and Diversity

Buch | Softcover
295 Seiten
2016 | Softcover reprint of the original 1st ed. 2013
Springer (Verlag)
978-94-024-0629-0 (ISBN)
179,98 inkl. MwSt
The book represents a comprehensive review and synthesis of the biomedical literature that spans over a half-century on a single protein called glyceraldehyde 3-phosphate dehydrogenase (or, GAPDH). Furthermore, GAPDH is highly conserved meaning that the protein found in microorganisms, such as pathogens, remained relatively unchanged in evolution.
The book represents a comprehensive review and synthesis of the biomedical literature that spans over a half-century on a single protein called glyceraldehyde 3-phosphate dehydrogenase (or, GAPDH). Due to the protein’s involvement in a vast array of cellular activities, GAPDH is of interest to the cell biologist, immunologist, virologist, biochemist etc. The protein has a significant role in fertility, cancer and neurodegeneration, suggesting that this book can be a vital resource for drug development. GAPDH function may provide insight into anesthesia. Furthermore, GAPDH is highly conserved meaning that the protein found in microorganisms, such as pathogens, remained relatively unchanged in evolution. Pathogens use GAPDH as a virulence factor, offering a unique challenge in developing anti-microbial agents that target this protein. To the evolutionary biologist, a book on the multi-functionality of GAPDH provides a focal point for a cogent discussion on the very origin of life.

1. Basic Biology of GAPDH. - 2. GAPDH and Intermediary Metabolism. - 3. Compartmentation of GAPDH. - 4. Functional Diversity. - 5. GAPDH, as a Virulence Factor. - 6. Target for Diverse Chemical Modifications. - 7. Dynamic Oligomeric Properties. - 8. Multiple Binding Partners. - 9. GAPDH in Anesthesia.

Erscheint lt. Verlag 23.8.2016
Reihe/Serie Advances in Experimental Medicine and Biology ; 985
Zusatzinfo XIV, 295 p.
Verlagsort Dordrecht
Sprache englisch
Maße 178 x 254 mm
Themenwelt Medizin / Pharmazie Studium
Naturwissenschaften Biologie Biochemie
Naturwissenschaften Chemie
Schlagworte Apoptosis • Cancer • glyceraldehyde 3-phosphate dehydrogenase • inhaled anesthetics • Neurodegeneration
ISBN-10 94-024-0629-8 / 9402406298
ISBN-13 978-94-024-0629-0 / 9789402406290
Zustand Neuware
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