Targeting the Broadly Pathogenic Kynurenine Pathway

Buch | Softcover

XV, 430 Seiten

2016 | 1. Softcover reprint of the original 1st ed. 2015
Springer International Publishing (Verlag)
978-3-319-36321-9 (ISBN)

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Tryptophan metabolism via kynurenine pathway plays a critical role in both health and a variety of human diseases. This book highlights the known associations between kynurenine pathway and various disease states, as well as examines the current status of drug development and clinical trials of compounds known to alter tryptophan metabolism. The research plays a critical role in molecular targeted therapies directed at altering the kynurenine pathway of tryptophan metabolism. The initial and rate-limiting step of tryptophan metabolism is mediated by one of two enzymes, tryptophan-2,3-dioxygenase (TDO; predominantly in the liver, but also in the brain) and indoleamine-2,3-dioxygenase (IDO; in a host of tissues in response to immune activation). Targeting the enzymes IDO and TDO, as well as other downstream effectors would therefore be likely to generate novel treatment options that would be helpful in a wide variety of clinical settings. This book provides a unique bridge between basic mechanistic understanding of the role of the kynurenine pathway with translational applications and clinical relevance. It will explore the indications that tryptophan metabolism is a potential biomarker of disease activity, can contribute to local and possibly systemic immune suppression in cancer, and is an attractive target for which a variety of inhibitors are readily available.

Part I. Overview.- Overview of the Kynurenine Pathway of Tryptophan Metabolism.- Role of Tryptophan Metabolism in Health and Disease.- Nutritional Aspects of Tryptophan Metabolism.- Role of Kynurenine Pathway in Early Brain Development.- Role of Kynurenine Pathway in Aging.- Role of Tryptophan Metabolism in Mood, Behavior, and Cognition.- Part II. Systemic Diseases.- Role of Kynurenine Pathway in Inflammatory Diseases.- Role of Kynurenine Pathway in Allergy.- Role of Kynurenine Pathway in HIV/AIDS.- Role of Kynurenine Pathway in Cardiovascular Disease.- Role of Kynurenine Pathway in Respiratory Diseases.- Role of Kynurenine Pathway in Gastrointestinal Diseases.- Role of Kynurenine Pathway in Insulin Resistance.- Role of Kynurenine Pathway in Infections.- Part III. CNS Disorders.- Role of Kynurenine Pathway in Neurodegenerative Diseases.- Role of Kynurenine Pathway in Epilepsy.- Role of Kynurenine Pathway in Stroke.- Role of Kynurenine Pathway in Pain and Migraines.- Role of Kynurenine Pathway in Autism Spectrum Disorders.- Role of Kynurenine Pathway in Neuropsychiatric Disorders.- Part IV. Oncology.- Role of Kynurenine Pathway in Stem Cell Biology.- Role of Kynurenine Pathway in Cancer Biology.- Role of Kynurenine Pathway in Neuro-oncology.- Role of the Kynurenine Pathway in Hematologic Malignancies.- Part V. Experimental Models and in Vivo Imaging.- Experimental Models to Study the Kynurenine Pathway.- Animal Models to Study the Role of Kynurenine Pathway in Mood, Behavior, and Cognition.- Applications of Small Animal PET Imaging.- Molecular Imaging of Serotonin Synthesis in the Brain.- Molecular Imaging of Tryptophan Metabolism.- Part VI. Therapeutic Approaches.- Inhibition of the Kynurenine Pathway of Tryptophan Catabolism.- Clinical Trials Targeting the Kynurenine Pathway.- The Next Decade in Tryptophan Metabolism Research.

Erscheinungsdatum	19.08.2017
Zusatzinfo	XV, 430 p.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	682 g
Themenwelt	Naturwissenschaften ► Biologie ► Allgemeines / Lexika
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
Schlagworte	Indoleamine-2,3-dioxygenase • Inflammation and cardiovascular disease • Kynurenine pathway • neurodegenerative diseases • Protein Structure • tryptophan-2,3-dioxygenase • Tryptophan metabolism
ISBN-10	3-319-36321-2 / 3319363212
ISBN-13	978-3-319-36321-9 / 9783319363219
Zustand	Neuware