Bioorganic Reactions – Mechanisms and Applications

Dr. V. Prakash Reddy is Professor of Chemistry at the Missouri University of Science and Technology. He has received a Ph.D. in Organic Chemistry from Case Western Reserve University, Cleveland, Ohio. He has had a distinguished academic career for over 20 years, and is an internationally recognized scientist, scholar, and teacher. He was an honorary member of the Golden Key National Honor Society at Case Western Reserve University. In recent years, at the Missouri University of Science and Technology, he has graduated many Ph.D. students who are well established in their academic an industrial careers. He has been a NASA Faculty Fellow at the Jet Propulsion Laboratory, California Institute of Technology.

FREE RADICAL INTERMEDIATES AND REACTIONS
-Introduction and background
- Free Radicals and Oxidative stress in Health and Disease
- Free radicals and lipid-autoxidations
- Cytochrome P450-catalysis in olefin epoxidations and aromatic hydroxylations
- Free radicals in cancer and age-related diseases

CARBOCATIONS AND ELECTROPHILIC SUBSTITUTION AND ADDITION REACTIONS
- Introduction and background
- Carbocation intermediates in enzyme-catalyzed reactions
- Electrophilic Addition Reactions

NUCLEOPHILIC SUBSTITUTION REACTIONS
- Introduction and background
- Enzyme-catalyzed nucleophilic substitution reactions (SN2, SNi, and SN1)
- Aromatic nucleophilic substitution reactions

CARBENES IN ENZYME-CATALYZED REACTIONS
- Introduction and background
- Carbenes in thiamine and cytochrome enzyme-catalyzed reactions

CARBANIONS AND ENOLATES
- Introduction and background (including outline of recent synthetic advances)
- Aldol reactions
- Michael additions
- Biological and medicinal significance of aldol reactions and Michael additions

NUCLEOPHILIC ADDITION REACTIONS TO CARBONYL COMPOUNDS
- Introduction and background
- Biochemically significant nucleophilic addition reactions

NUCLEOPHILIC ACYL-SUBSTITUTION REACTIONS
- Introduction and background
- Biochemically relevant nucleophilic acyl substitution reactions

PERICYCLIC REACTIONS AND THEIR BIOLOGICAL SIGNIFICANCE
- Sigmatropic rearrangements
- Cycloadditions
- Molecular rearrangements in enzyme-catalyzed reactions

BIOLOGICAL REDOX REACTIONS
- Introduction and background
- Catalytic antibodies in oxidations
- Cytochrome P450-catalyzed oxidations of amines
- Monoamine oxidases (MAO) in oxidative deaminations
- Synthetic metalloenzymes in olefin epoxidations and dihydroxylations
- NADPH-dependent oxidoreductases