Infrared and Raman Spectroscopy

Peter J. Larkin leads Solvay's Spectroscopy and Materials Characterization group based in Stamford, Connecticut. He has more than 25 years of experience using IR, Raman, and NIR spectroscopy in the chemical and pharmaceutical industry. This includes managing research groups in R&D environments as well as directing analytical method development, validation, and transfer teams. He specializes in IR and Raman spectral interpretation, spectroscopic chemometric analyses, early phase API and chemical development support, and process analytical techniques (PAT). Dr. Larkin received his PhD from the University of Pittsburgh in 1990 using resonance Raman and vibrational circular dichroism spectroscopy to study heme proteins. Since that time he has worked in analytical departments both in the specialty chemical and pharmaceutical industries. While at American Cyanamid/Cytec Industries in Stamford, CT, Larkin received comprehensive training in IR interpretation from Dr. Norman B. Colthup. He subsequently worked at Wyeth Pharmaceutical, had a brief stint with Pfizer, lead the solid state analysis group at Bristol-Myers Squibb, and now leads the spectroscopy and materials characterization group at Solvay.

1. Introduction: Infrared and Raman Spectroscopy2. Basic Principles3. Instrumentation and Sampling Methods4. Environmental Dependence of Vibrational Spectra5. Origin of Group Frequencies6. IR and Raman Spectra-Structure Correlations: Characteristic Group Frequencies7. General Outline and Strategies for infrared and Raman Spectral Interpretation8. Illustrated IR and Raman Spectra Demonstrating Important Functional Groups9. Unknown IR and Raman Spectra

Appendix: IR Correlation Charts