Statistical Approaches in Oncology Clinical Development
Chapman & Hall/CRC (Verlag)
978-1-4987-7269-3 (ISBN)
The book covers all aspects of cancer clinical trial starting from early phase development. The early part of the book covers novel phase I dose escalation design, exposure response analysis, and innovative phase II design. This includes early development strategy for cancer immunotherapy trials. The contributors also emphasized the role of biomarker and modern era of precision medicine. The second part focuses on the late stage development. This includes the application of adaptive design, safety analysis, and quality of life (QoL) data analysis. The final part discusses current regulatory perspective and challenges.
Features:
Covers a wide spectrum of topics related to real-life statistical challenges in oncology clinical trials.
Provides a comprehensive overview of novel statistical methods to improve trial design and statistical analysis.
Detailed case studies illustrate the real life applications.
Satrajit Roychoudhury is a Senior Director and a member of the Statistical Research and Innovation group in Pfizer Inc. Prior to joining; he was a member of Statistical Methodology and consulting group in Novartis. He has 11 years of extensive experience in working with different phases of clinical trial. His area of research includes early phase oncology trials, survival analysis, model informed drug development, and use of Bayesian methods in clinical trials. He is industry co-chair for the ASA Biopharmaceutical Section Regulatory-Industry Workshop and has provided statistical training in major conferences including the Joint Statistical Meetings, ASA Biopharmaceutical Section Regulatory-Industry Workshop, and ICSA Applied Statistics Symposium.
Soumi Lahiri has 12 years of extensive experience in working different therapeutic areas. She is the former Director of Biostatistics in Clinical Oncology, GlaxoSmithKline. She has also worked in the oncology division of Novartis Pharmaceutical Company for two years. She is an active member of the ASA Biopharmaceutical section and former chair of the membership committee.
Satrajit Roychoudhury is a Senior Director and a member of the Statistical Research and Innovation group in Pfizer Inc. Prior to joining; he was a member of Statistical Methodology and consulting group in Novartis. He has 11 years of extensive experience in working with different phases of clinical trial. His area of research includes early phase oncology trials, survival analysis, model informed drug development, and use of Bayesian methods in clinical trials. He is industry co-chair for the ASA Biopharmaceutical Section Regulatory-Industry Workshop and has provided statistical training in major conferences including the Joint Statistical Meetings, ASA Biopharmaceutical Section Regulatory-Industry Workshop, and ICSA Applied Statistics Symposium. Soumi Lahiri has 12 years of extensive experience in working different therapeutic areas. She is the former Director of Biostatistics in Clinical Oncology, GlaxoSmithKline. She has also worked in the oncology division of Novartis Pharmaceutical Company for two years. She is an active member of the ASA Biopharmaceutical section and former chair of the membership committee.
1. Introduction 2. Statistical Considerations in Phase I Oncology Trials 3. Exposure–Response Analysis in Oncology Trials 4. Statistical Measures of Interaction for Evaluating a Predictive Biomarker 5. Design Considerations for Phase II Oncology Clinical Trials 6. Precision Medicine and Associated Challenges 7. Use of Adaptive Design in Late-Stage Oncology Trials 8. Safety Monitoring and Analysis in Oncology Trials 9. Quality of Life 10. Impact of Evolving Regulatory Pathways on Statistical Considerations in Oncology Clinical Trials
Erscheinungsdatum | 23.11.2018 |
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Reihe/Serie | Chapman & Hall/CRC Biostatistics Series |
Zusatzinfo | 29 Tables, black and white; 50 Illustrations, black and white |
Sprache | englisch |
Maße | 156 x 234 mm |
Gewicht | 498 g |
Themenwelt | Mathematik / Informatik ► Mathematik ► Statistik |
Studium ► Querschnittsbereiche ► Epidemiologie / Med. Biometrie | |
Naturwissenschaften ► Biologie | |
Technik | |
ISBN-10 | 1-4987-7269-2 / 1498772692 |
ISBN-13 | 978-1-4987-7269-3 / 9781498772693 |
Zustand | Neuware |
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