Polyketides

Richard Taylor is Professor of Chemistry & Biochemistry and Associcate Dean for Research at the University of Notre Dame, Indiana (USA). He received his B.S. degree in chemistry from SUNY Oswego, 1987, and his M.S. and Ph.D. degrees from Rensselaer Polytechnic Institute under the direction of the late Arthur G. Schultz, 1992. From 1992-1995, he did postdoctoral work with Professor Paul A. Wender at Stanford University, working on a total synthesis of the anticancer natural product taxol. In 1995 he began his independent career at the University of Notre Dame as an Assistant Professor and rose to his current rank of Professor of Chemistry in 2004. He co-founded the Walther Cancer Research Center at the University of Notre Dame where he now serves as a principal investigator and a member of the executive committee. His honors and awards include the National Science Foundation Early Career Award, the Eli Lilly Grantee Award, and undergraduate teaching awards. In 2010, he was elected Fellow of the American Association for the Advancement of Science. He is a co-author of over 60 independent papers and his research interests include the use of synthetic and biosynthetic techniques to prepare biologically active polyketides and investigate their chemotherapeutic potential. Christopher N. Boddy is Associate Professor at the Department of Chemistry at the University of Ottawa (Canada) since 2008. He studied chemistry at the University of Alberta, Canada, and received his PhD with Prof. K. C. Nicolaou at The Scripps Research Institute, La Jolla (USA), in 2001. He was a postdoctoral fellow in the group of Prof. Phil Dawson at the Department of Cell Biology at the same institute and then moved to Stanford University to do postdoctoral work with Prof. Chaitan Khosla. From 2004 - 2008, he was appointed assistant professor at the Department of Chemistry, Syracuse University, USA. He is a recipient of the Early Researcher Award 2010-2015 by the Ministry of Research and Innovation and his major research interests revolve around natural product biosynthesis, synthetic chemistry, biochemistry, molecular microbiology, and metabolic engineering.

I. BASIC PATHWAYS OVERVIEW 1. Type I (Macrolide Antibiotics: Erythromycin and Pikromycin) 2. Type II Polyketides (Enterocin) 3. Type III Polyketides (Resveratrol) 4. Fungal Polyketides (lovastatin) 5. Mixed NRPS-PKS (Epothilones) 6. Post PKS 1: Methyl Transferases 7. Post PKS 2: Epoxidases 8. Post PKS 3: Glycosidases (Apoptolidin) 9. Post PKS 4: Oxidoreductases (Spirangien) II. ADVANCED TOPICS 10. Beta-branching (Curacin) 11. Trans-AT (Pederin) 12. Skipping/Iterative/Non-linearity (Aureothin / Borrelidin) 13. Polyethers (Monensin) 14. Engineering (Doramectin) 15. Metagenomes (Bryostatin) III. APPENDIX/GLOSSARY