Tuberculosis and the Tubercle Bacillus

William R. Jacobs, Jr., Helen McShane, Valerie Mizrahi, Ian Orme

Section 1: Towards Edward Jenner’s Revenge: Developing an Effective Tuberculosis Vaccine A. Basic Immunology


1 Innate Immune Responses to Tuberculosis Jeffrey S. Schorey and Larry S. Schlesinger


2 Cytokines and Chemokines in Mycobacterium tuberculosis Infection Racquel Domingo-Gonzalez et al.


3 Regulation of Immunity to Tuberculosis Susanna Brighenti and Diane J. Ordway


4 The Memory Immune Response to Tuberculosis Joanna R. Kirman, Marcela I. Henao-Tamayo, and Else Marie Agger


5 Pathology of Tuberculosis: How the Pathology of Human Tuberculosis Informs and Directs Animal Models Randall J. Basaraba and Robert L. Hunter B. Animal Models


6 Animal Models of Tuberculosis: An Overview Ann Williams and Ian M. Orme


7 Mouse and Guinea Pig Models of Tuberculosis Ian M. Orme and Diane J. Ordway


8 Non-Human Primate Models of Tuberculosis Juliet C. Peña and Wen-Zhe Ho


9 Experimental Infection Models of Tuberculosis in Domestic Livestock Bryce M. Buddle, H. Martin Vordermeier, and R. Glyn Hewinson C. Vaccines


10 Clinical Testing of Tuberculosis Vaccine Candidates Mark Hatherill, Dereck Tait, and Helen McShane D. Human Immunology


11 Human Immunology of Tuberculosis Thomas J. Scriba, Anna K. Coussens, and Helen A. Fletcher


12 The Immune Interaction between HIV-1 Infection and Mycobacterium tuberculosis Elsa du Bruyn and Robert John Wilkinson


Section 2: Drug Discovery and Development: State of the Art and Future Directions


13 Preclinical Efficacy Testing of New Drug Candidates Eric L. Nuermberger


14 Oxidative Phosphorylation as a Target Space for Tuberculosis: Success, Caution, and Future DirectionsGregory M. Cook et al.


15 Targeting Phenotypically Tolerant Mycobacterium tuberculosis Ben Gold and Carl Nathan


Section 3: Biomarkers and Diagnostics


16 Tuberculosis Diagnostics: State of the Art and Future Directions Madhukar Pai, Mark P. Nicol, and Catharina C. Boehme


17 Latent Mycobacterium tuberculosis Infection and Interferon-Gamma Release Assays Madhukar Pai and Marcel Behr


18 Impact of the GeneXpert MTB/RIF Technology on Tuberculosis Control Wendy Susan Stevens et al.


Section 4: Host and Strain Diversity


19 The Role of Host Genetics (and Genomics) in Tuberculosis Vivek Naranbhai


20 The Evolutionary History, Demography, and Spread of the Mycobacterium tuberculosis Complex Maxime Barbier and Thierry Wirth


21 Impact of Genetic Diversity on the Biology of Mycobacerium tuberculosis Complex Strains Stefan Niemann et al.


22 Evolution of Mycobacterium tuberculosis: New Insights into Pathogenicity and Drug Resistance Eva C. Boritsch and Roland Brosch


Section 5: The Signature Problem of Tuberculosis Persistence


23 Acid-Fast Positive and Acid-Fast Negative Mycobacterium tuberculosis: The Koch Paradox Catherine Vilchèze and Laurent Kremer


24 Mycobacterial Biofilms: Revisiting Tuberculosis Bacilli in Extracellular Necrotizing Lesions Randall J. Basaraba and Anil K. Ojha


25 Killing Mycobacterium tuberculosis In Vitro: What Model Systems Can Teach Us Tracy L. Keiser and Georgiana E. Purdy


26 Epigenetic Phosphorylation Control of Mycobacterium tuberculosis Infection and ersistence Melissa Richard-Greenblatt and Yossef Av-Gay


27 DNA Replication in Mycobacterium tuberculosis Zanele Ditse, Meindert H. Lamers, and Digby F. Warner


28 The Sec Pathways and Exportomes of Mycobacterium tuberculosisBrittany K. Miller, Katelyn E. Zulauf, and Miriam Braunstein


29 The Role of ESX-1 in Mycobacterium tuberculosis Pathogenesis Ka-Wing Wong


30 The Minimal Unit of Infection: Mycobacterium tuberculosis in the Macrophage Brian C. VanderVen et al.


31 Metabolic Perspectives on Persistence Travis E. Hartman et al.


32 Phenotypic Heterogeneity in Mycobacterium tuberculosis Neeraj Dhar, John McKinney, and Giulia Manina


33 Mycobacterium tuberculosis in the Face of Host-Imposed Nutrient Limitation Michael Berney and Linda Berney-Meyer