Tuberculosis and the Tubercle Bacillus

Table of Contents


Introduction

I. Historical Perspectives

1. Global Burden of Tuberculosis: Past, Present, and Future, Liz Corbett and Mario Raviglione
II. Clinical and Epidemiological Perspectives

2. Overview of Clinical Tuberculosis, Philip C. Hopewell and Robert M. Jasmer
3. Molecular Epidemiology of Mycobacterium tuberculosis, M. Donald Cave, Megan Murray, and Edward Nardell
III. Diagnostics

4. Clinical Mycobacteriology (Tuberculosis) Laboratory: Services and Methods, Leonid Heifets and Edward Desmond
5. Immune-Based Methods, Suman Laal and Yasir A. W. Skeiky
6. Molecular Diagnosis of Mycobacterial Infections, Betty A. Forbes, Gaby Pfyffer, and Kathleen D. Eisenach
IV. Current Therapies and Drug Resistance

7. Global Impact of Multidrug Resistance, Marcos A. Espinal and Max Salfinger
8. Mechanisms of Drug Resistance in Mycobacterium tuberculosis, Ying Zhang, Catherine Vilcheze, and William R. Jacobs, Jr.
The Organism Mycobacterium tuberculosis

V. Genomics

9. Introduction to Functional Genomics of the Mycobacterium tuberculosis Complex, Priscille Brodin, Caroline Demangel, and Stewart T. Cole
10. Comparative Genomics and Evolution of Mycobacterium bovis BCG, Roland Brosch and Marcel A. Behr
11. TB or Not TB: a Structural Genomics Mission? Celia W. Goulding, Debnath Pal, and David Eisenberg
VI. Genetics

12. Gene Replacement Systems, Neil G. Stoker, P. Sander, and J. M. Reyrat
13. Repetitive DNA in the Mycobacterium tuberculosis Complex, Stephen V. Gordon and Philip Supply
14. Mycobacteriophages and Tuberculosis, Graham F. Hatfull
15. Control of Mycobacterial Transcription, Issar Smith, William R. Bishai, and Valakunja Nagaraja
VII. Cell Structure

16. The Proteome of Mycobacterium tuberculosis, John T. Belisle, Miriam Braunstein, Ida Rosenkrands, and Peter Andersen
17. The Cell Envelope of Mycobacterium tuberculosis with Special Reference to the Capsule and Outer Permeability Barrier, Philip Draper and Mamadou Daffe
18. Structure, Biosynthesis, and Genetics of the Myolic Acid-Arabinogalactan-Peptidoglycan Complex, Sebabrata Mahapatra, Joyoti Basu, Patrick J. Brennan, and Dean C. Crick
19. A Waxy Tale, by Mycobacterium tuberculosis, Laurent Kremer and Gurdyal S. Besra
VIII. Metabolism

20. General Metabolism and Biochemical Pathways of Tubercle Bacilli, Paul R. Wheeler and John S. Blanchard
21. Iron Metabolism in the Tubercle Bacillus and Other Mycobacteria, Luis E. N. Quadri and Colin Ratledge
22. Two-Component Systems, Protein Kinases, and Signal Transduction in Mycobacterium tuberculosis, Yossef Av-Gay and Vojo Deretic
23. Nucleic Acid Metabolism, Valerie Mizrahi, Michael Buckstein, and Harvey Rubin
24. Transport Processes, Jean Content, Martine Braibant, Nancy D. Connell, and Jose A. Ainsa
Host-Pathogen Interactions

IX. Phagocytic Uptake and Intracellular Survival

25. Receptor-Mediated Recognition of Mycobacterium tuberculosis by Host Cells, Matthew J. Fenton, Lee W. Riley, and Larry S. Schlesinger
26. Mycobacterium tuberculosis: the Indigestible Microbe, David G. Russell
27. Intracellular Models of Mycobacterium tuberculosis Infection, John Chan, Richard Silver, Beate Kampmann, and Robert S. Wallis
28. Dendritic Cells in Host Immunity to Mycobacterium tuberculosis, Marc Mendelson, Willem Hanekom, and Gilla Kaplan
X. Host Immune Responses and Antigenic Variation

29. CD8 T Cells in Tuberculosis, Stefan H. E. Kaufmann and JoAnne L. Flynn
30. CD1 and Tuberculosis, Christopher C. Dascher and Michael B. Brenner
31. Th1 and Th2 Cytokines in the Human Immune Response to Tuberculosis, Peter F. Barnes and Ramakrishna Vankayalapati
32. Role of Antibody-Mediated Immunity in Host Defense against Mycobacterium tuberculosis, Aharona Glatman-Freedman and Arturo Casadevall
33. The PE and PPE Multigene Families of Mycobacteria, Michael J. Brennan, Nico C. Gey van Pittius, and Clara Espitia
XI. Animal Models

34. Mycobacterium marinarum and Fish and Frog Models of Infection, Michele Trucksis, Christopher L. Pritchett, and Renate Reimschuessel
35. Experimental Infection Models of Tuberculosis in Domestic and Wild Animals, Bryce M. Buddle, John M. Pollock, and R. Glyn Hewinson
36. Animal Models of Tuberculosis, JoAnne L. Flynn, Andrea M. Cooper, and William Bishai
37. Tuberculosis Vaccine Preclinical Screening and Development, Ian M. Orme and Angelo A. Izzo