Prostate Cancer: Shifting from Morphology to Biology

Foreword. Preface. List of contributors. I Clues to morphological diagnosis and prognosis evaluation.-Update on diagnostic criteria, on biopsy and surgical specimen: pre-invasive lesions, from epithelial cell hyperplasia to carcinoma in situ invasive carcinoma. First-line immunophenotyping of prostate diseases.- II Molecular pathology.- Molecular determinants of cancer-related inflammation.- Apoptosis and autophagy.- Androgen receptor and steroidogenesis pathways.- Neuroendocrine differentiation – role of somatostatin receptors (SSTRs) for diagnosis, prognosis, and therapy.- Metastatic dissemination.- Resistance to castration - resistance to drugs.- Crossroads of signaling pathways. III Genetic and Epigenetic Events in prostate cancer.- Gene polymorphisms.- Expression signature.- Mapping prostate cancer aggressiveness loci.- Epigenetic mechanisms: histone acetylation, DNA methylation, miRNA, chromatin modifiers. IV A modern approach to therapy of prostate cancer: targeting the deadly subset.-Molecular markers for patient selection and stratification: personalized prognostic predictive models.- Targeting tumor angiogenesis.- Efficacy of signal transduction inhibition in advanced prostate cancer.- Therapeutic targeting of the bone pre-metastatic niche.- Counteracting hypoxia in radio-resistant metastatic lesions.- “Synthetic lethality”: molecular co-targeting to restore the DNA.- Repair mechanisms in prostate cancer cells concluding remarks. Index.