Diagnostic Devices with Microfluidics

Francesco Piraino is currently a research scientist at the Swiss Federal Institute of Technology in Lausanne (Switzerland). He uses microscale technologies to develop next-generation microfluidic diagnostics platforms. Following his graduate studies in Biomedical Engineering at Politecnico di Milano (Italy) and at Harvard-MIT Division of Health Science & Technology (USA), he joined the Broad Institute of MIT and Harvard (USA) to develop devices for single-cell genomics. Dr. Piraino is a trained bioengineer who has also attended programs at the Universitat de Barcelona (Spain), the City College of the City University of New York (USA), and the Massachusetts Institute of Technology (USA). His work aims to solve problems at the intersection of biomedical engineering and medicine. His research interests include in vitro diagnostics, tissue engineering, and biomaterials. Šeila Selimović is director of the NIBIB programs in tissue chips/tissue preservation technologies and biosensors. Her other scientific interests include lab-on-a-chip platforms, paper microfluidics, and point-of-care diagnostics. In 2015, she was selected as one of the "50 Leaders of Tomorrow" from among hundreds of young biotech leaders in the Mid-Atlantic region. Prior to her current position, she was chosen by the American Association for the Advancement of Science to serve as a Science and Technology Policy Fellow at the U.S. Department of State, where she covered science diplomacy issues related to energy security, climate, and innovation. Previously, she was a postdoctoral research fellow at Harvard Medical School and Brigham and Women’s Hospital in Boston, Massachusetts. Dr. Selimović’s research has focused on the development of microfluidic platforms for applications in biophysics and biological engineering, and her research interests include the physics of microscale flows, protein crystallization, colloidal suspensions, and rheology and microrheology. Dr. Selimović earned her PhD and MSc in physics from Brandeis University, with National Science Foundation support, and her BA in physics and German from Wellesley College. She is a member of Sigma Xi.

Preface

Series Editor

Editors

Contributors

Section I Microfluidic Devices for Diagnostics

1. Handheld Microfluidics for Point-of-Care

In Vitro Diagnostics

2. Body-Worn Microfluidic Sensors

3. Fabrication and Applications of Paper-Based Microfluidics

4. Printed Wax-Ink Valves for Multistep Assays in Paper

Analytical Devices

5. Mycofluidics: Miniaturization of Mycotoxin Analysis

6. Planar Differential Mobility Spectrometry for

Clinical Breath Diagnostics

Section II Applications in Disease Detection

7. Rapid Diagnosis of Infectious Diseases Using

Microfluidic Systems

8. Microfluidics for Tuberculosis Diagnosis: Advances,

Scalability, and Challenges

Section III Practical Aspects of Developing

a Commercial Diagnostic Device

9. Starting with the End in Mind by Developing Diagnostics

around User Needs

10. Incorporating the Needs of Users into the Development of

Diagnostics for Global Health: A Framework and Two Case

Studies

Index