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Signaling-Mediated Control of Cell Division (eBook)

From Oogenesis to Oocyte-to-Embryo Development

Swathi Arur (Herausgeber)

eBook Download: PDF

2017 | 1st ed. 2017
X, 292 Seiten
Springer International Publishing (Verlag)
978-3-319-44820-6 (ISBN)

Lese- und Medienproben

Ebook-Leseprobe (PDF)

This volume covers the current knowledge base on the role of signaling and environmental pathways that control the normal development of germline stem cells, meiotic progression of oocytes, events of oocyte maturation and fertilization, and the birth of an embryo.

Germ cells are uniquely poised to sustain life across generations through the fusion of oocyte and sperm. Because of the central importance of germ cells to life, much work has been dedicated to obtaining a clear understanding of the molecular and signaling events that control their formation and maintenance. Germ cells are set aside from somatic cells in the embryo and go through specialized meiotic cell cycles as the animal matures. These cell cycles are interspersed with long periods of arrest. In human females, meiosis I is initiated in the fetus. At birth, oocytes are arrested in meiosis I; after puberty, every month an oocyte initiates meiosis II - ovulation. Upon sperm availability these cells are fertilized, generate an embryo, and the cycle-of-life continues. During meiotic I progression and arrest, the fitness of oocytes and their progeny are likely influenced by environmental cues and signaling pathways.

A lot of recent work has focused on understanding the mechanisms that regulate oocyte fitness and quality in humans and vertebrates. Much of our understanding on the events of meiosis I and germline stem cell populations comes from work in invertebrates, wherein the germline stem cells produce oocytes continuously through adult development. In both inverbrates and vertebrates nutritional and signaling pathways control the regulation of stem cells in such a manner so as to couple production of gametes with the nutritional availability. Additionally, mature oocytes arrest both in meiosis I and meiosis II, and signaling and nutritional pathways have been shown to regulate their formation, and maintenance, such that despite long periods of arrest, the oocyte quality is assured and errors in chromosome segregation and varied cytoplasmic events are minimal.

1. Role of chromatin modifications in germline stem cell differentiationPooja Flora, Maitreyi Upadhyay , Alicia McCarthy, Prashanth Rangan Prashanth Rangan prangan@albany.edu2. Regulation of the balance between proliferation and differentiation in germline stem cells.Ramya Singh and David HansenDavid Donald Hansen dhansen@ucalgary.ca3. Control of germ line stem cell lineages by diet and physiologyKaitlyn Laws and Daniela Drummond-BarbosaDaniela Barbosa dbarbosa@jhu.edu4. Signal-mediated regulation of meiotic prophase I during oogenesisKenneth Trimmer and Swathi ArurSwathi Arur sarur@mdanderson.org5. Prophase I: preparing chromosomes for segregation in the developing oocyteRachel Harney, Benjamin Alleva, Sarit SmolikovSarit Smolikov saritsmol@gmail.com6. Translational control of germ cell decisionsKumari Pushpa, Amaresh Chaturbedi, Ganga Anil Kumar and Kuppuswamy SubramaniamK Subramaniam subbu@iitm.ac.in7. Prostagladin signaling from oocyte to spermHieu Dinh Hoang and Michael MillerMichael Miller mamiller@uab.edu8. Cell fate maintenance and reprogramming during the oocyte-to-embryotransition’Christina Fassnacht and Rafal CioskRafal Ciosk rafal.ciosk@fmi.ch9. Maternal to zygotic transitions across evolutionRueyling Lin rueyling.lin@utsouthwestern.edu10 Cell cycle regulation in oocytesKubiak JZ and Borsuk EUniversity of Rennes, FranceJacek Kubiak. jacek.kubiak@univ-rennes1.fr11 Oocyte activation and fertilization: crucial sperm and oocyte factorsMarc Yeste, Celine Jones, Siti N. Amdani, Kevin CowardUniversity of OxfordMarc Yeste. marc.yeste@obs-gyn.ox.ac.uk

Erscheint lt. Verlag	28.2.2017
Reihe/Serie	Results and Problems in Cell Differentiation
Zusatzinfo	X, 292 p. 37 illus., 34 illus. in color.
Verlagsort	Cham
Sprache	englisch
Themenwelt	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Technik
Schlagworte	Cell Cycle Analysis • Embryo development • gene expression • Germ cells • germline • oocytes • Oogenesis • Stem Cells
ISBN-10	3-319-44820-X / 331944820X
ISBN-13	978-3-319-44820-6 / 9783319448206

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